Lymph node ratio as an independent prognostic factor in cN0 floor of mouth squamous cell carcinoma: A single-institution retrospective cohort analysis

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-28 DOI:10.1016/j.amjoto.2025.104644

Duy Quoc Ngo , Thang Manh Hoang , Trong Van Nguyen , Quy Xuan Ngo

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引用次数: 0

Abstract

Background

To analyze the influence of lymph node ratio (LNR) in survival of clinically node-negative (cN0) patients with floor of mouth squamous cell carcinoma (FMSCC).

Materials and methods

Clinicopathologic data from 48 patients with cN0 FMSCC who underwent curative surgery and selective neck dissection from 2015 to 2020 was retrospectively assessed. The impact of LNR and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses.

Results

Occult nodal metastases were identified in 11 patients (22.9 %). The mean lymph node yield was 13.94 ± 7.11 nodes. ROC curve analysis identified an optimal LNR threshold of 0.034, with an area under the curve of 0.691 (p = 0.03). In the multivariate analysis, LNR was an independent prognostic factor for both OS (HR 9.018, 95 % CI 3.214–25.306, p < 0.001) and DFS (OR 12.889, 95 % CI 2.426–68.473, p = 0.002). Patients with LNR >0.034 demonstrated significantly inferior 5-year OS rates (26.7 % versus 89.1 %).

Conclusions

The LNR is an independent prognostic factor in cN0 FMSCC patients. An LNR threshold of 0.034 effectively stratifies risk and may guide adjuvant therapy decisions.

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淋巴结比例作为口腔鳞状细胞癌cN0底的独立预后因素：一项单机构回顾性队列分析

背景：分析淋巴结比例（LNR）对临床淋巴结阴性（cN0）口腔底鳞状细胞癌（FMSCC）患者生存的影响。材料与方法回顾性分析2015 - 2020年收治的48例cN0型FMSCC患者的临床病理资料。通过单因素和多因素分析分析LNR和其他变量对总生存期（OS）和无病生存期（DFS）的影响。结果11例（22.9%）患者出现结节性转移。平均淋巴结清扫率为13.94±7.11个。ROC曲线分析发现，最佳LNR阈值为0.034，曲线下面积为0.691 （p = 0.03）。在多因素分析中，LNR是两种OS的独立预后因素(HR 9.018, 95% CI 3.214-25.306, p <；0.001)和DFS （OR 12.889, 95% CI 2.426 ~ 68.473, p = 0.002）。LNR >；0.034的患者5年OS率明显低于前者（26.7% vs 89.1%）。结论LNR是影响FMSCC患者预后的独立因素。LNR阈值为0.034，可以有效地对风险进行分层，并可指导辅助治疗决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

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