Multicomponent Metallacages via the Integrative Self-Assembly of Pt(II) Nodes with Multiple Pyridyl and Carboxylate Ligands

Abstract

In recent years, multicomponent self-assembly has emerged as a pivotal strategy in supramolecular chemistry, enabling the construction of artificial systems with enhanced functionalities that surpass those of individual molecular components. These assemblies have garnered significant interest due to their potential applications in molecular recognition, catalysis, and biomedical engineering. However, achieving precise control over the assembly process remains a significant challenge, as increased structural complexity often results in thermodynamic mixtures, limiting their practical applications. In this context, metal-coordination-driven multicomponent self-assembly has emerged as a promising strategy, as the moderate strength and good directionality of metal–ligand bonds ensure the formation of discrete supramolecular architectures with well-defined structures and geometries. Notably, the integration of pyridyl and carboxylate donors with cis-Pt(II) nodes offers an effective approach for constructing multicomponent metallacages. This method is particularly attractive due to its ability to enable precise heteroleptic assembly, along with the accessibility and tunability of the ligands, which impart desirable photophysical properties and potential anticancer activities.