Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Traumatic Brain Injury Patients Undergoing Emergency Craniotomy Surgery: A Retrospective Study

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-05-02 DOI:10.1155/ijcp/8880629

Yun-Qi Wang, Xian-Jie Zhang, Dan Zhou, Qing Li, Xin Liu

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引用次数: 0

Abstract

Background: The purpose of this study was to investigate the effect of dexmedetomidine (DEX) on the incidence of postoperative posttraumatic stress disorder (PTSD) in traumatic brain injury (TBI) patients undergoing emergency craniotomy.

Methods: The TBI patients who underwent emergency craniotomy at our hospital from January 2017 to June 2023 were included in our study. The patients were divided into the DEX group and the control group. We analyzed the intraoperative data (bradycardia, hypotension, hypoxemia, duration of anesthesia, and duration of surgery) and the postoperative data (PTSD, the total length of hospital stay, and Glasgow Coma Scale [GCS] scores at discharge).

Results: A total of 126 TBI patients were included in our study. Of these patients, 55 were treated with DEX (the mean rate of administration was 0.58 ± 0.22 μg/kg/h.) and 71 did not receive DEX. The incidence of bradycardia was significantly higher in the DEX group than in the control group (p < 0.05). However, the incidence of PTSD was significantly higher in the control group than in the DEX group (p < 0.05).

Conclusion: The use of DEX during anesthesia was effective in reducing the incidence of postoperative PTSD in TBI patients undergoing craniotomy.

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右美托咪定对急诊开颅颅脑损伤患者创伤后应激障碍的影响：回顾性研究

背景：本研究的目的是探讨右美托咪定（DEX）对创伤性脑损伤（TBI）患者急诊开颅手术后创伤后应激障碍（PTSD）发生率的影响。方法：选取2017年1月至2023年6月在我院行急诊开颅手术的TBI患者为研究对象。将患者分为DEX组和对照组。我们分析了术中数据（心动过缓、低血压、低氧血症、麻醉时间和手术时间）和术后数据（创伤后应激障碍、总住院时间和出院时格拉斯哥昏迷评分）。结果：本研究共纳入126例TBI患者。55例患者给予DEX治疗（平均给药率0.58±0.22 μg/kg/h）， 71例患者未给予DEX治疗。DEX组的心动过缓发生率明显高于对照组(p <；0.05)。然而，对照组PTSD的发生率明显高于DEX组(p <；0.05)。结论：麻醉时使用右美托咪唑能有效降低颅脑外伤患者开颅手术后PTSD的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.