Co/Ampyrone-MOF as a Green Nanocatalyst for One-Pot Synthesis of Xanthene Derivatives

Abstract

In the present work, Co/Ampyrone-MOF was synthesized via the solvothermal method. The synthesized Co/Ampyrone-MOF was then analyzed using various methods, including SEM, EDX, XRD, and FT-IR. This metal–organic framework (MOF) was employed as a heterogeneous nanocatalyst in the preparation of xanthene derivatives (3a-3j) through a one-pot, solvent-free condensation reaction. The reaction involved combining two moles of dimedone (2) with one mole of aldehydes (1) at temperatures between 60°C and 70°C. This simple and efficient method resulted in a high yield of xanthene derivatives, short reaction times, and an easy purification process with no unwanted by-products. Prepared compounds (3a-3j) underwent PASS online analysis, which revealed that the compounds have displayed inhibitory activity against testosterone 17beta-dehydrogenase, so a molecular docking study was performed for compounds (3a-3j) with 1JTV target. The docking results showed a good affinity of the prepared xanthene derivatives to bind with 1JTV protein in comparison with steroidal compound STX1040.