Construction of Light and Temperature-Responsive Acrylamide Copolymer-Metal Organic Frameworks for Breast Cancer Therapy

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-10-19 DOI:10.1007/s10904-024-03378-9

Tingting Chen, Yangling Xiao, Guan Fang

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Abstract

Breast cancer is a common and increasingly prevalent female tumor. Current treatments include surgery, radiation, and drug therapy, but these often result in high recurrence rates and significant side effects. Thus, developing new therapeutic drugs for breast cancer remains a clinical priority. We synthesized an intelligent drug delivery system, polyacrylamide-polypyrrole (PAM-PPy), through radical copolymerization and combined it with CP1@1 to construct a light and heat-responsive drug delivery platform. The synthesized PAM-PPy@CP1@1 was characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (FESEM), and Thermogravimetric Analysis (TG). This designed system was used to load the newly synthesized compound 1. When compound 1 was encapsulated in PAM-PPy@CP1, its cumulative release reached 67.01% after 6 h of near-infrared (NIR) irradiation at pH 7.4. During the controlled release of compound 1, PAM-PPy acted as a photothermal transducer, converting NIR radiation into heat while maintaining the temperature within its responsive range. Additionally, PAM-PPy functioned as a gatekeeper, preventing the burst release of compound 1. In vitro cell experiments assessed its inhibitory activity on the proliferation of breast cancer cells. Our study provides a platform for developing breast cancer therapeutics.

Graphical Abstract

A photothermal-responsive drug delivery platform, PAM-PPy@CP1@1, was constructed, and the inhibitory activity of the system on the proliferation of breast cancer cells was evaluated using in vitro cellular assays, providing a platform for the development of therapies for breast cancer.

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光和温度响应丙烯酰胺共聚物-金属有机框架的构建用于乳腺癌治疗

乳腺癌是一种常见且日益流行的女性肿瘤。目前的治疗方法包括手术、放疗和药物治疗，但这些方法往往导致高复发率和显著的副作用。因此，开发新的治疗乳腺癌的药物仍然是临床的优先事项。我们通过自由基共聚合成了一种智能给药系统聚丙烯酰胺-聚吡咯（PAM-PPy），并将其与CP1@1结合，构建了一个光热响应的给药平台。利用傅里叶红外光谱（FT-IR）、扫描电镜（FESEM）和热重分析（TG）对合成的PAM-PPy@CP1@1进行了表征。该系统用于装载新合成的化合物1。化合物1包封在PAM-PPy@CP1中，在pH 7.4的近红外（NIR）照射6 h后，其累积释放量达到67.01%。在化合物1的受控释放过程中，PAM-PPy充当光热换能器，将近红外辐射转化为热量，同时将温度保持在其响应范围内。此外，PAM-PPy还起到了看门人的作用，阻止了化合物1的释放。体外细胞实验评估了其对乳腺癌细胞增殖的抑制作用。我们的研究为开发乳腺癌治疗方法提供了一个平台。构建光热响应给药平台PAM-PPy@CP1@1，通过体外细胞实验评价该系统对乳腺癌细胞增殖的抑制活性，为乳腺癌治疗方案的开发提供平台。

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.