Synthesis, Characterization and in Vitro Drug Delivery Applications of a Tin-Based Metal‒Organic Framework

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-10-15 DOI:10.1007/s10904-024-03397-6

Akriti Sharma, Archana Thakur

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Abstract

This study reports an efficient and fast, microwave-assisted synthesis of a tin-based metal‒organic framework (Sn-MOF), followed by ibuprofen (IBU) drug loading and subsequent encapsulation in carboxymethyl cellulose (CMC) for drug delivery applications. The Sn-MOF was synthesized using trithiocyanuric acid (TCA), stannous chloride dihydrate, and N, N-dimethyl formamide (DMF) at 200 °C within six minutes using microwave-assisted synthesis. The structural and morphological properties of the synthesized Sn-MOF were studied using IR, ¹³C NMR, FESEM (field emission scanning electron microscopy), powder XRD, and TGA analyses. FESEM images revealed the presence of pores on the surface of the complex and flower-shaped microstructures. The ibuprofen drug was effectively loaded into the Sn-MOF structure, as indicated by the shifts in the peaks in the IR spectra. Further encapsulation in carboxymethyl cellulose and crosslinking with ferric chloride resulted in CMC/Sn-MOF@IBU being pH responsive and sustained drug delivery. The demonstrated swelling behaviour, encapsulation efficiency, and in vitro release make CMC/Sn-MOF@IBU a potential candidate for drug delivery of ibuprofen. The kinetics of drug release and predictive modelling further validated the sustained release of the drug from the CMC/Sn-MOF@IBU matrix.

Graphical Abstract

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锡基金属有机骨架的合成、表征及其体外给药应用

本研究报道了一种高效、快速的微波辅助合成锡基金属有机骨架（Sn-MOF），随后将布洛芬（IBU）载药并随后包封在羧甲基纤维素（CMC）中用于药物递送应用。以三硫氰尿酸（TCA）、二水合氯化亚锡和N， N-二甲基甲酰胺（DMF）为原料，在200℃下，微波辅助合成6分钟，合成了Sn-MOF。采用IR、13C NMR、FESEM（场发射扫描电子显微镜）、粉末XRD和TGA分析对合成的Sn-MOF进行了结构和形态表征。FESEM图像显示，在复杂的花状微结构表面存在孔隙。从红外光谱峰的位移可以看出，布洛芬药物被有效地装入Sn-MOF结构中。进一步包封在羧甲基纤维素中，并与氯化铁交联，CMC/Sn-MOF@IBU具有pH响应性和持续的药物递送。CMC/Sn-MOF@IBU具有良好的溶胀性能、包封效率和体外释放性，是布洛芬给药的潜在候选药物。药物释放动力学和预测模型进一步验证了药物从CMC/Sn-MOF@IBU基质的缓释。图形抽象

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.