Investigating the Antimicrobial, Antioxidant and Anticancer Activities of Sr and Fe Doped TiO2-Folic Acid Nanocomposite: Potential Therapeutic Applications

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-10-15 DOI:10.1007/s10904-024-03421-9

Takveer Singh, Surbhi Dhadda, Shikhar Gupta, Sanketsinh Thakore, Samaksh Goyal, Soumya V Menon, Saleh H. Salmen, Arunachalam Chinnathambi

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引用次数: 0

Abstract

Nanoscale TiO₂-based materials are gaining popularity in the healthcare sector due to their antimicrobial properties, low cost, and adaptable physicochemical characteristics. Despite extensive research, their high biological compatibility along with biocidal activities fall short till date. Herein, Sr and Fe ion doped titanium dioxide conjugated with folic acid nanocomposite (TiO₂SrFeFA) is synthesized and studied for antibacterial, antifungal, and anticancer properties. As-synthesized TiO₂SrFeFA nanocomposite exhibit spherical morphology with anatase phase, efficiently doped Sr and Fe ion, and embedded in folic acid matrix. TiO₂SrFeFA shows excellent antibacterial activity against Staphylococcus aureus, Staphylococcus pneumoniae, Bacillus subtilis, Klebsiella pneumoniae, Shigella dysenteriae and Escherichia coli; antifungal activity against Candida albicans; anticancer activity against breast cancer MOLT-4 cell and antioxidant activity. The effectiveness of Sr and Fe ion doped titanium dioxide nanoparticles conjugated with FA demonstrated the nanomaterial’s potential as a biocompatible biocidal agent.

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研究锶和铁掺杂tio2 -叶酸纳米复合材料的抗菌、抗氧化和抗癌活性：潜在的治疗应用

纳米级二氧化钛基材料由于其抗菌性能、低成本和适应性强的物理化学特性，在医疗保健领域越来越受欢迎。尽管有广泛的研究，但它们的高生物相容性和生物杀灭活性仍然不足。本文合成了锶和铁离子掺杂二氧化钛与叶酸缀合的纳米复合材料（TiO2SrFeFA），并对其抗菌、抗真菌和抗癌性能进行了研究。合成的TiO2SrFeFA纳米复合材料具有锐钛矿相的球形形貌，有效地掺杂了Sr和Fe离子，并包埋在叶酸基质中。TiO2SrFeFA对金黄色葡萄球菌、肺炎葡萄球菌、枯草芽孢杆菌、肺炎克雷伯菌、痢疾志贺氏菌和大肠埃希氏菌具有良好的抑菌活性；抗白色念珠菌活性；抗乳腺癌MOLT-4细胞及抗氧化活性锶和铁离子掺杂的二氧化钛纳米颗粒与FA共轭的有效性证明了纳米材料作为生物相容性杀菌剂的潜力。

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.