Mucoadhesive Polymer Tangeretin Loaded Chitosan Nanoparticles to Combat the Resistance of Mycobacterium Tuberculosis

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-10-28 DOI:10.1007/s10904-024-03428-2

Yu-chen Zheng, Run-ze Qiu, Xin Da, Guang-chuan Dai, Xiang-rong Zhang

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引用次数: 0

Abstract

Present methods of care the recommended course of treatment for Mycobacterium tuberculosis (MTB) resistance involves taking first-line medications orally for 4–6 months. Nonetheless, serious negative consequences result from this strategy. For the purpose of treating MTB resistance, chitosan nanoparticles (CSNPs) have been the subject of extensive research into controlled release drug delivery systems. A chitosan nanoparticle encapsulated O-polymethoxylated flavone called tangeretin was used in this investigation. Several approaches were used to characterize this nanoparticle (TN-CSNPs) that were successfully obtained. Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Staphylococcus aureus, Klebsiella pneumoniae, and TB resistant strains were tested for antimicrobial activity in both planktonic and biofilm development phases. Utilizing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test in treated cells, the bioavailability of the nanoparticles has been evaluated. The TN-CSNPs demonstrated enhanced inhibitory effectiveness against both planktonic and adhering MTB strains, as well as resistant strains compared to chitosan alone treated groups. Additionally, the nanoparticles that were tested were found to be biocompatible with MRC-5 fibroblast cells. This suggests that they could be used to create novel therapeutic agents that are effective against MTB and other multidrug-resistant infections.

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黏附聚合物橘皮苷负载壳聚糖纳米颗粒对抗结核分枝杆菌耐药性

目前的护理方法和针对结核分枝杆菌耐药性的推荐疗程包括口服一线药物4-6个月。然而，这一策略产生了严重的负面后果。为了治疗结核分枝杆菌耐药性，壳聚糖纳米颗粒（csnp）已成为控释给药系统的广泛研究对象。用壳聚糖纳米粒包封o -多甲氧基黄酮，称为橘皮素。我们使用了几种方法来表征这种成功获得的纳米颗粒（tn - csnp）。对鲍曼不动杆菌、铜绿假单胞菌、肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌和结核耐药菌株在浮游和生物膜发育阶段的抗菌活性进行了测试。利用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四唑（MTT）试验，对纳米颗粒的生物利用度进行了评估。与壳聚糖单独处理组相比，tn - csnp对浮游和粘附MTB菌株以及耐药菌株的抑制效果均增强。此外，测试的纳米颗粒被发现与MRC-5成纤维细胞具有生物相容性。这表明它们可以用来创造新的治疗药物，有效对抗MTB和其他耐多药感染。

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.