Fenugreek-enriched electrospun PLA scaffold: revolutionizing tissue engineering solutions

IF 2.6 4区化学 Q3 POLYMER SCIENCE

Journal of Polymer Research Pub Date : 2025-05-02 DOI:10.1007/s10965-025-04373-5

Hemalatha Parangusan, K. Karuppasamy, Jolly Bhadra

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引用次数: 0

Abstract

The therapeutic properties of medicinal plants have been harnessed to facilitate wound healing, and conventional techniques for their application in this regard have been devised. Electrospun nanofibrous scaffolds have recently shown great potential as materials for tissue engineering, specifically tissue regeneration. Utilizing medicinal plant components in nanofibers for biomedical and wound healing purposes holds promise for improving performance and achieving a synergistic outcome. The scaffolds that were created underwent analysis using X-ray diffraction, Fourier transform, mechanical testing, swelling measurement, contact angle measurement, and weight loss assessment. The study also examined the compatibility of the cells with the scaffolds and assessed their wound-healing capacity in a laboratory setting. The scanning electron microscopy (SEM) images of the PLA and PLA/fenugreek composite scaffolds demonstrate the presence of uniform, sleek, and flawless nanofibers. The investigation yielded significant evidence regarding the in vitro wound healing and cell viability of 3 T3 fibroblast cells on the produced scaffolds. The findings demonstrated that PLA scaffolds with fenugreek exhibit promising potential as substitutes for tissue engineering purposes.

Graphical Abstract

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胡芦巴苷丰富的静电纺PLA支架：革命性的组织工程解决方案

药用植物的治疗特性已被利用来促进伤口愈合，并已设计出在这方面应用它们的常规技术。近年来，电纺纳米纤维支架在组织工程特别是组织再生方面显示出巨大的潜力。利用纳米纤维中的药用植物成分用于生物医学和伤口愈合，有望提高性能并实现协同效果。所制备的支架进行了x射线衍射、傅里叶变换、力学测试、膨胀测量、接触角测量和减重评估等分析。该研究还检查了细胞与支架的相容性，并在实验室环境中评估了它们的伤口愈合能力。PLA和PLA/葫芦巴复合支架的扫描电子显微镜（SEM）图像显示存在均匀，光滑和完美的纳米纤维。实验结果表明，所制备的支架对3种T3成纤维细胞的体外创面愈合和细胞活力有显著影响。研究结果表明，含胡芦巴的聚乳酸支架在组织工程领域具有良好的替代潜力。图形抽象

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来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.