Rehmannia glutinosa polysaccharides alleviate cyclophosphamide-induced immunosuppression by enhancing immunity and restoring intestinal homeostasis

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-04-30 DOI:10.1016/j.ijbiomac.2025.143692

Lin Yu, Xiaofeng Shi, Xuanqi Lu, Xuping Zhao, Yaming Yu, Yushan Fang, Deyun Wang

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引用次数: 0

Abstract

This study investigated the immunomodulatory effects of Rehmannia glutinosa polysaccharides (RGP) in a cyclophosphamide (CTX)-induced immunosuppression model. RGP treatment alleviated weight loss, immune organ atrophy, and hematological abnormalities, restored B and T cell populations, and enhanced the immune function. It strengthened intestinal barrier integrity by upregulating tight junction proteins, increasing goblet cell numbers, and promoting IgA secretion, while also reducing pro-inflammatory cytokines and increasing IL-10 levels. RGP further regulated the gut microbiota composition, increasing beneficial bacteria and reducing pathogens, while promoting SCFA production and improving metabolic homeostasis. These findings highlight RGP as a potential natural immunomodulator, supporting further research into its molecular mechanisms and clinical applications.

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地黄多糖通过增强免疫和恢复肠道稳态来缓解环磷酰胺诱导的免疫抑制

研究地黄多糖（RGP）对环磷酰胺（CTX）诱导的免疫抑制模型的免疫调节作用。RGP治疗减轻了体重下降、免疫器官萎缩和血液学异常，恢复了B细胞和T细胞群，增强了免疫功能。它通过上调紧密连接蛋白，增加杯状细胞数量，促进IgA分泌，同时减少促炎细胞因子和增加IL-10水平，增强肠屏障的完整性。RGP进一步调节肠道菌群组成，增加有益菌群，减少致病菌，同时促进短链脂肪酸的产生，改善代谢稳态。这些发现强调了RGP作为一种潜在的天然免疫调节剂，支持对其分子机制和临床应用的进一步研究。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.