Association between brain resting-state functional activities and obesity: A bidirectional Mendelian randomization study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-04-28 DOI:10.1016/j.clnesp.2025.04.016

Zhaoyi Chen , Jinkun Wang , Tianli Lyu , Qiuyu Xia , Lu Liu , Bin Li

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引用次数: 0

Abstract

Background

Investigations revealed significant changes in brain activity between people with obesity or overweight and people with normal weight. The causal relationship between body weight and brain functional activity remains unclear and warrants further investigation.

Methods

We conducted a bidirectional two-sample Mendelian randomization (MR) study. We gathered summary statistics from genome-wide association studies for 191 resting-state functional magnetic resonance imaging phenotypes and obesity traits (body mass index, body fat percentage, waist-to-hip ratio). Inverse variance weighting, the weighted median, MR Egger, and the weighted mode were employed. We conducted pleiotropy and heterogeneity analyses to evaluate robustness and reliability.

Results

Forward analysis revealed that the intensity of spontaneous brain activity in the calcarine, lingual, or cuneus gyri within the visual network (beta = −0.076; 95 % CI: −0.11 to −0.04; p = 6.97 × 10⁻⁵) had a causal effect on body weight. The reverse analysis revealed that body weight has a causal effect on the intensity of spontaneous brain activity in the precuneus, angular, and cingulate gyri (beta = 0.209; 95 % CI: 0.11 to 0.31; p = 2.41 × 10⁻⁵), and the angular and temporal gyri (beta = 0.215; 95 % CI: 0.11 to 0.32; p = 3.87 × 10⁻⁵) within the default mode and central executive network.

Conclusions

Genetic evidence proves a causal relationship between body weight and brain functional activity.

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脑静息状态功能活动与肥胖之间的关系：一项双向孟德尔随机研究

调查显示，肥胖或超重人群与正常体重人群的大脑活动有显著变化。体重和脑功能活动之间的因果关系尚不清楚，值得进一步研究。方法采用双向双样本孟德尔随机化（MR）研究。我们从191个静息状态功能性磁共振成像表型和肥胖特征（体重指数、体脂率、腰臀比）的全基因组关联研究中收集了汇总统计数据。采用方差逆加权法、加权中位数法、MR Egger法和加权模式。我们进行了多效性和异质性分析来评估稳健性和可靠性。结果前向分析显示，视觉网络内胼胝体、舌部和楔脑区的自发脑活动强度(β = - 0.076；95% CI:−0.11 ~−0.04；P = 6.97 × 10−5)对体重有因果影响。反向分析显示，体重对楔前叶、角回和扣带回的自发脑活动强度有因果关系(β = 0.209；95% CI: 0.11 ~ 0.31；P = 2.41 × 10−5)，角回和颞回(beta = 0.215；95% CI: 0.11 ~ 0.32；P = 3.87 × 10−5)在默认模式和中央执行网络。结论遗传证据证明体重与脑功能活动之间存在因果关系。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.