Minor salivary gland tumors: A retrospective review of cases in a single centre of south Italy

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-28 DOI:10.1016/j.amjoto.2025.104650

Ida Barca , Francesco Ferragina , Samuel Staglianò , Giuseppe Tarallo , Angelo Ruggero Sottile , Maria Grazia Ioppolo , Marco Frasca , Maria Giulia Cristofaro

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引用次数: 0

Abstract

Purpose

Tumors of the minor salivary glands (TMSGs) are rare with heterogeneous behavior despite their low frequency. This study aimed to investigate their distribution characteristics in a single centre of south Italy during the last 10 years and to compare them with similar studies done elsewhere.

Materials and methods

A retrospective study of TMSGs was performed in 110 patients. Data were analyzed using SPSS version 25, Kaplan-Meier analysis was used to find the survival and the outcome hazard ratio was calculated for each variable using Cox regression.

Results

110 patients with TMSGs (55 female ad 55 male, median age 61 years) was examined, including 34 benign and 76 malignant lesions. The palate was the most commonly affected site (41.81 %) in both benign and malignant tumors and the most frequent histological type was respectively pleomorphic adenoma and adenoid cystic carcinoma. Overall survival at 5 years was estimated at 92 %, with statistically significant values for histological high risk and pathological TNM (p value 0.048 and 0.032). Recurrence free survival at 5 years is equal to 82 %.

Conclusion

TMSGs have good overall survival despite recurrences. The most significant predictors of outcome are pathological stage and histological risk group.

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小唾液腺肿瘤：在意大利南部单一中心的病例回顾性审查

目的小唾液腺肿瘤（TMSGs）虽发病率低，但少见，且具有异质性。这项研究的目的是调查它们在过去10年里在意大利南部一个单一中心的分布特征，并将它们与其他地方进行的类似研究进行比较。材料与方法对110例患者的tmsg进行回顾性研究。数据分析采用SPSS version 25， Kaplan-Meier分析计算生存率，Cox回归计算各变量的结局风险比。结果共检查TMSGs患者110例（女55例，男55例，中位年龄61岁），其中良性病变34例，恶性病变76例。在良、恶性肿瘤中，腭均为最常见的受累部位（41.81%），最常见的组织学类型分别为多形性腺瘤和腺样囊性癌。5年总生存率估计为92%，组织学高风险和病理性TNM的统计值具有统计学意义（p值分别为0.048和0.032）。5年无复发生存率为82%。结论tmsg虽有复发，但总生存率较高。最重要的预后预测因子是病理分期和组织学危险组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.