Photoredox-Catalyzed Trifluoromethylamination of Alkenes with Concomitant Introduction of a Quinoxalin-2(1H)-one Moiety

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-02 DOI:10.1021/acs.joc.5c00400

Meiyu Zhang, Shuai Liu, Weidong Meng, Yangen Huang

引用次数: 0

Abstract

A photoredox-catalyzed strategy for the difunctionalization of alkenes with quinoxalin-2(1H)-ones and N-CF₃ hydroxylamine reagents was developed. This reaction was carried out under photoirradiation conditions, affording the corresponding three-component coupling products in moderate to high yields with excellent regioselectivity. It provides a new protocol to access valuable quinoxalin-2(1H)-one derivatives containing a N-CF₃ group.

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伴随引入喹啉-2(1H)- 1片段的光氧化还原催化烯烃三氟甲基层化反应

研究了喹啉-2(1H)-酮和N-CF3羟胺光氧化催化烯烃双官能化的方法。该反应在光辐射条件下进行，得到了相应的三组分偶联产物，产率中高，具有优异的区域选择性。它为获得含有N-CF3基团的有价值的喹诺沙林-2(1H)- 1衍生物提供了新的方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.