Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-05-02 DOI:10.1002/adma.202504057

Xuzheng Liu, Yaning Zhao, Xiaoyi Wu, Yueli Zhou, Yingheng Liu, Shilei Wang, Yufeng Zhang, Hongye Yang, Fangfang Song, Cui Huang

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Abstract

Various biomaterials have been developed to address challenging critical-sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral ossification (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the functionality of the greenhouse ecosystem, herein a bionic niche is innovatively crafted to recapitulate the ECO process. This niche consists of three hierarchical components: an embedded microchannel network that facilitates cell infiltration and matter exchange, a polydopamine surface modification layer with immunomodulatory functions, and an ECO-targeted delivery system based on mesoporous silica nanoparticles. Through spatiotemporally programming of the microenvironment, the bionic niche effectively recapitulates the key stages of ECO. Notably, even in the rat calvaria, a region well-known for IMO, the bionic niche is capable of initiating ECO, evident by cartilage template formation, leading to efficient bone regeneration. Taken together, this study introduces prospective concepts for designing next-generation ECO-driven biomaterials for bone tissue engineering.

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时空编程微环境通过温室仿生生态位重现软骨内骨化

各种生物材料已经被开发出来，以解决具有挑战性的临界尺寸的骨缺陷。然而，它们大多集中在膜内骨化（IMO）而不是软骨内骨化（ECO），往往导致治疗效果不理想。从温室生态系统的功能中汲取灵感，这里创新地制作了一个仿生生态位，以再现生态系统的过程。该生态位由三个层次组成：促进细胞浸润和物质交换的嵌入式微通道网络，具有免疫调节功能的聚多巴胺表面修饰层，以及基于介孔二氧化硅纳米颗粒的eco靶向递送系统。通过对微环境的时空规划，仿生生态位有效地概括了生态系统的关键阶段。值得注意的是，即使在大鼠颅部（一个众所周知的IMO区域），仿生生态位也能够启动ECO，这可以通过软骨模板的形成来证明，从而导致有效的骨再生。综上所述，本研究介绍了设计下一代骨组织工程生态驱动生物材料的前瞻性概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.