Utilizing Mode-Division Multiplexing for Multicell Trapping

IF 4.3 2区综合性期刊 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Sensors Journal Pub Date : 2025-03-27 DOI:10.1109/JSEN.2025.3553389

Bingjie Bi;Cun Zhao;Chunlei Jiang;Penghui Dai;Hongda Jiang;Peng Chen;Xiufang Wang;Yu Sun;Xu Liu

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引用次数: 0

Abstract

We propose a novel single-fiber optical tweezers technology based on mode-division multiplexing (MDM) using LP₀₁, LP₁₁, and LP₂₁ modes. This method enables effective coupling between multimode fibers (MMFs) and single-mode fibers (SMFs) through precise coaxial splicing. By exciting multiple modes in the MMF and employing the SMF for mode filtering, we selectively retain the LP₀₁, LP₁₁, and LP₂₁ modes while effectively suppressing higher order modes. Additionally, we have designed and fabricated an abruptly tapered fiber (ATF) probe to converge the beams of different modes, generating distinct focused light fields at the probe’s tip and sides. The simulation and experimental results indicate that this technology can establish multiple stable optical traps, allowing for the effective trapping of several cells. This approach provides precise manipulation tools for studying interactions, such as collective sensing and metabolic cooperation among cells, demonstrating significant application potential, particularly in single-cell analysis, multicellular assembly, and biological micromanipulation.

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利用模分复用实现多小区捕获

我们提出了一种基于模分复用（MDM）的新型单光纤镊子技术，使用LP01、LP11和LP21模式。该方法通过精确的同轴拼接实现了多模光纤（mmf）和单模光纤（smf）之间的有效耦合。通过在MMF中激发多个模式并使用SMF进行模式滤波，我们可以选择性地保留LP01， LP11和LP21模式，同时有效地抑制高阶模式。此外，我们还设计并制造了一种突变锥形光纤（ATF）探头，用于汇聚不同模式的光束，在探头的尖端和侧面产生不同的聚焦光场。仿真和实验结果表明，该技术可以建立多个稳定的光阱，从而有效地捕获多个细胞。这种方法为研究细胞间的集体传感和代谢合作等相互作用提供了精确的操作工具，在单细胞分析、多细胞组装和生物微操作方面具有重要的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Sensors Journal 工程技术-工程：电子与电气

CiteScore

7.70

自引率

14.00%

发文量

2058

审稿时长

5.2 months

期刊介绍： The fields of interest of the IEEE Sensors Journal are the theory, design , fabrication, manufacturing and applications of devices for sensing and transducing physical, chemical and biological phenomena, with emphasis on the electronics and physics aspect of sensors and integrated sensors-actuators. IEEE Sensors Journal deals with the following: -Sensor Phenomenology, Modelling, and Evaluation -Sensor Materials, Processing, and Fabrication -Chemical and Gas Sensors -Microfluidics and Biosensors -Optical Sensors -Physical Sensors: Temperature, Mechanical, Magnetic, and others -Acoustic and Ultrasonic Sensors -Sensor Packaging -Sensor Networks -Sensor Applications -Sensor Systems: Signals, Processing, and Interfaces -Actuators and Sensor Power Systems -Sensor Signal Processing for high precision and stability (amplification, filtering, linearization, modulation/demodulation) and under harsh conditions (EMC, radiation, humidity, temperature); energy consumption/harvesting -Sensor Data Processing (soft computing with sensor data, e.g., pattern recognition, machine learning, evolutionary computation; sensor data fusion, processing of wave e.g., electromagnetic and acoustic; and non-wave, e.g., chemical, gravity, particle, thermal, radiative and non-radiative sensor data, detection, estimation and classification based on sensor data) -Sensors in Industrial Practice