Neuroblastoma olfatorio: revisión de literatura y presentación de dos casos clínicos con diferentes infiltraciones tumorales y diferentes abordajes

IF 0.7 4区医学 Q4 NEUROSCIENCES

Neurocirugia Pub Date : 2025-05-01 DOI:10.1016/j.neucir.2024.10.002

Carlos A. Ferreira , Carlos E. Quevedo , Gina V. Vilardy , Mario Andrés Arias Depablos

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引用次数: 0

Abstract

The olfactory neuroblastoma is a rare malignant neoplasm derived from the olfactory neuroepithelium. It can metastasize to cervical lymph node chains and distant organs through hematogenous or lymphatic routes. Two clinical cases are presented: the first, a 56-year-old man with no pathological history, exhibited symptoms evolving over 2 months, characterized by persistent rhinorrhea with frequent epistaxis, ipsilateral proptosis, left hemicranial pain, anosmia, and dysgeusia. Radiological images showed involvement of paranasal sinuses, left orbital cavity, and intracranial region. The second case involved a 46-year-old male with progressive symptoms over more than 1 year, including nasal obstruction, rhinorrhea, self-limited epistaxis, anosmia, weight loss in the last 3 months, and subjective decrease in visual acuity. A protruding mass in the left nasal fossa was observed without intracranial involvement. Both cases were pathologically and immunohistochemically consistent with olfactory neuroblastoma, Hyams grade 2.

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嗅觉神经母细胞瘤：两个具有不同肿瘤浸润和不同治疗方法的临床病例的文献综述和介绍

嗅觉神经母细胞瘤是一种罕见的源自嗅觉神经上皮的恶性肿瘤。它可以通过血液或淋巴途径转移到颈部淋巴结链和远处器官。本文报告两例临床病例：第一例为56岁男性，无病理史，症状发展超过2个月，特征为持续性鼻漏伴频繁鼻出血、同侧突出、左半颅疼痛、嗅觉缺失和发音障碍。影像学显示鼻窦、左眶腔及颅内受累。第二例患者为46岁男性，症状进行性超过1年，包括鼻塞、鼻漏、自限性鼻出血、嗅觉丧失、近3个月体重减轻和主观视力下降。左鼻窝一突出肿块，未累及颅内。两例病理和免疫组织化学均符合嗅神经母细胞瘤，Hyams 2级。

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来源期刊

Neurocirugia 医学-神经科学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

60 days

期刊介绍： Neurocirugía is the official Journal of the Spanish Society of Neurosurgery (SENEC). It is published every 2 months (6 issues per year). Neurocirugía will consider for publication, original clinical and experimental scientific works associated with neurosurgery and other related neurological sciences. All manuscripts are submitted for review by experts in the field (peer review) and are carried out anonymously (double blind). The Journal accepts works written in Spanish or English.