DABCO-catalyzed [3+4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives

IF 9.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chinese Chemical Letters Pub Date : 2024-11-13 DOI:10.1016/j.cclet.2024.110646

Ke Wu , Xiuqin Ruan , Shuolei Jia, Enyuan Wang, Qingfa Zhou

引用次数: 0

Abstract

A [3 + 4] annulation of α-substituted allenes and Schiff bases is reported. This methodology serves as a conduit for the construction of a series of biologically important benzazepine derivatives in good to excellent yields under mild conditions by an unprecedented mode involving β′-carbon of α-substituted allenes and the proposed mechanism is supported by capturing the intermediate. Moreover, this class of benzazepine derivatives exhibited potential ability of cytotoxicity toward cancer cells.

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dabco催化席夫碱与α-取代烯的[3+4]环：功能化苯二氮衍生物的构建

报道了α-取代烯和席夫碱的A[3 + 4]环化。该方法为构建一系列具有重要生物学意义的苯二氮衍生物提供了途径，在温和条件下，通过α-取代烯的β′-碳的前所未有的模式，获得了良好的收率，并通过捕获中间体支持了所提出的机制。此外，这类苯氮卓衍生物对癌细胞具有潜在的细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.