Retinal vascular density in different refractive errors assessed by optical coherence tomography angiography

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-04-18 DOI:10.1016/j.pdpdt.2025.104600

Hemn Baghban Jaldian , Zhale Rajavi , Parva Pourbagherkhah , Hossein Mohammad-Rabei , Mohammadmehdi Hatami , Mohammad Farjami , Hamideh Sabbaghi

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引用次数: 0

Abstract

Purpose

To compare retinal vascular density (VD) in individuals with different refractive errors using Optical Coherence Tomography Angiography (OCTA) and evaluate the correlation between VD and ocular biometric parameters.

Methods

This study included 56 participants with moderate myopia and hyperopia, along with 33 controls with lower levels of refractive errors. The mean age of participants was 28.95 ± 6.92 years for the case group and 31.18 ± 6.81 years for the controls. Among the participants, 51.7 % were female. All subjects underwent OCTA imaging using the RTVue XR Avanti system to measure VD in the superficial and deep capillary plexuses. The foveal avascular zone (FAZ) area was also assessed.

Results

Myopic eyes exhibited a significantly higher deep capillary plexus (DCP) foveal VD compared to hyperopic eyes (P = 0.031). In hyperopic eyes, there was a significant positive correlation between anterior chamber depth (ACD) and superficial capillary plexus (SCP) VD (P < 0.001), while in myopic eyes, age was negatively correlated with SCP foveal VD (P = 0.009). Additionally, the FAZ area showed a negative correlation with ACD in both hyperopic and control eyes (P < 0.05).

Conclusions

Myopic eyes demonstrated higher DCP foveal VD compared to hyperopic eyes, suggesting distinct vascular characteristics among different refractive errors. OCTA provides valuable insights into microvasculature changes in eyes with refractive errors.

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光学相干断层血管造影评估不同屈光不正视网膜血管密度

目的利用光学相干断层血管造影（OCTA）比较不同屈光不正患者的视网膜血管密度（VD），探讨VD与眼部生物特征参数的相关性。方法本研究包括56名中度近视和远视患者，以及33名屈光不正程度较低的对照组。病例组和对照组的平均年龄分别为28.95±6.92岁和31.18±6.81岁。在参与者中，51.7%是女性。所有受试者均使用RTVue XR Avanti系统进行OCTA成像，测量浅、深毛细血管丛VD。中央凹无血管区（FAZ）面积也进行了评估。结果近视眼深毛细血管丛（DCP）中央凹VD明显高于远视眼（P = 0.031）。远视时，前房深度（ACD）与浅毛细血管丛（SCP） VD (P <；而在近视组，年龄与SCP中央凹VD呈负相关（P = 0.009）。远视眼和对照眼的FAZ面积与ACD呈负相关(P <；0.05)。结论屈光不正近视眼的DCP中央凹VD高于远视眼，不同屈光不正的血管特征不同。OCTA为屈光不正患者的微血管变化提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.