Advancing ovarian cancer management: Role of nucleic acid biomarkers and novel therapeutic approaches

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-05-01 DOI:10.1016/j.genrep.2025.102241

Rutuja Deshmukh, Sharav A. Desai, Vipul P. Patel, Sakshi Narote, Nikita Raut

引用次数: 0

Abstract

Ovarian cancer is the most common malignant neoplasm affecting women in the reproductive tract, characterized by high relapse rates, elevated mortality, and an unfavourable prognosis. Early detection and diagnosis of ovarian cancer are crucial for improving patient survival rates. Nucleic acid biomarkers play a vital role in cancer progression, influencing tumor suppressor genes and oncogenes while maintaining epigenetic stability. These biomarkers are integral in developing diagnostic tests and evaluating prognosis. This review highlights the diagnostic potential of nucleic acid-based molecules, which serve as therapeutic agents to improve patients' quality of life. This review discusses recent advancements in the use of RNA interference, antisense oligonucleotides, CRISPR/Cas9 technology, and aptamers in the detection and treatment of ovarian cancer. These innovative approaches hold promise for enhancing early detection and therapeutic efficacy, paving the way for more personalized treatments.

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推进卵巢癌管理：核酸生物标志物的作用和新的治疗方法

卵巢癌是影响妇女生殖道最常见的恶性肿瘤，其特点是复发率高，死亡率高，预后不良。卵巢癌的早期发现和诊断对于提高患者的生存率至关重要。核酸生物标志物在癌症进展中发挥重要作用，影响肿瘤抑制基因和癌基因，同时保持表观遗传稳定性。这些生物标志物在开发诊断测试和评估预后中是不可或缺的。这篇综述强调了基于核酸的分子的诊断潜力，它可以作为治疗药物来改善患者的生活质量。本文综述了RNA干扰、反义寡核苷酸、CRISPR/Cas9技术和适体在卵巢癌检测和治疗中的最新进展。这些创新的方法有望提高早期发现和治疗效果，为更个性化的治疗铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.