Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-04-29 DOI:10.1016/j.ijbiomac.2025.143645

Chao Yan , XuChun Zhu , Yingying Ren , Shanyue Guan , Shan He , Feng Qiu , Mingzheng Huang , Xiaozhong Qu , Hongzhi Liu

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Abstract

Ischemic stroke (IS), characterized by acute cerebral vascular occlusion and narrow therapeutic windows, poses formidable clinical challenges due to the blood-brain barrier (BBB) restriction, reperfusion injury risks, and limited efficacy of conventional thrombolytic therapies. These hurdles necessitate advanced delivery systems capable of precise BBB penetration, remodeled circulation, and neuroprotection. Proteins and peptides emerge as universal biomaterials for constructing nano-delivery platforms, leveraging their biocompatibility, biodegradability, low toxicity, and receptor-specific targeting. This review systematically explores protein-based nanomaterials in stroke intervention, emphasizing material selection, fabrication strategies, and therapeutic applications. Various structural proteins are analyzed for their unique advantages in carrier design, while peptide modifications are highlighted for enhancing targeted delivery. Critical fabrication techniques are discussed to balance stability and functionality. Furthermore, the applications of protein-based nanomaterials in IS therapy are summarized. Advanced preparation and application of protein-based nanomaterials, from delivery vehicles to ligand modification, potentially prolong the therapeutic window for IS and provide effective neuroprotection.

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基于蛋白质的纳米传递系统：蛋白质材料、制造策略及其在缺血性卒中干预中的应用综述

缺血性脑卒中（IS）以急性脑血管闭塞、治疗窗口狭窄为特征，由于血脑屏障（BBB）限制、再灌注损伤风险以及常规溶栓治疗的疗效有限，给临床带来了巨大挑战。这些障碍需要能够精确穿透血脑屏障、重塑循环和保护神经的先进输送系统。蛋白质和多肽利用其生物相容性、可生物降解性、低毒性和受体特异性靶向性，成为构建纳米递送平台的通用生物材料。这篇综述系统地探讨了基于蛋白质的纳米材料在卒中干预中的应用，强调了材料的选择、制造策略和治疗应用。分析了各种结构蛋白在载体设计中的独特优势，同时强调了肽修饰以增强靶向递送。讨论了平衡稳定性和功能性的关键制造技术。综述了蛋白质基纳米材料在IS治疗中的应用。蛋白质基纳米材料的先进制备和应用，从递送载体到配体修饰，有可能延长IS的治疗窗口期，并提供有效的神经保护。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.