Recent progress of antibacterial strategy for 3D-printed bone repair scaffold

Abstract

3D-printed scaffolds have become one of the most effective methods for treating bone injuries due to their customizable porous structure and biodegradability, which avoids secondary surgery. To prevent bacterial infections during clinical procedures, the introduction of antibacterial functionality is a necessary design for 3D-printed scaffolds. Excellent antibacterial strategies can provide scaffolds with overall better performance while maintaining satisfactory antibacterial effects, providing great potential for the advancement of scaffolds in bone tissue engineering. This work reviews different antibacterial strategies and research progress of 3D-printed scaffolds in recent years, including antibacterial drug release, non-pharmacological antibacterial, and antibacterial coatings.