Riesgo similar de hospitalización y letalidad por COVID-19 en trasplantados y pacientes en lista de espera: un análisis comparativo

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI:10.1016/j.eimc.2024.12.007

Abelardo Claudio Fernández Chávez , Guillermo Yovany Ordoñez León , Eva Elisa Álvarez León , Paloma Moreno Nuñez , José Porto Tomás , Jesús María Aranaz Andrés

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引用次数: 0

Abstract

Introduction

In 2022, Spanish health authorities recommended passive immunization against COVID-19 for solid organ transplant recipients (SOT), due to their deficient post-vaccination humoral response. Patients on the transplant waiting list (SOTwl) were excluded from this strategy.

Objective

To compare the risk of hospitalization, ICU admission, and mortality due to COVID-19 between SOT and SOTwl patients.

Methods

Patients seen in the Preventive Medicine Department at Ramón y Cajal Hospital between 03/14/2020 and 04/13/2022. The relative risk (RR) of hospitalization, ICU admission, and mortality was estimated among SOT and SOTwl patients, adjusted for age, sex, and vaccine doses.

Results

A total of 1292 patients were analyzed. SOT patients (n = 1153) were older and had similar risks of hospitalization (RR 0.97, 95% CI 0.57-1.64), ICU admission (RR 1.74, 95% CI 0.44-6.86), and death (RR 0.89, 95% CI 0.45-1.77) compared to SOTwl patients (n = 139).

Conclusion

The risks of hospitalization, ICU admission, and mortality were similar between SOT and SOTwl patients.

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2019冠状病毒病对移植和等候名单患者的类似住院和致命性风险：比较分析

2022年，西班牙卫生当局建议对实体器官移植受者（SOT）进行COVID-19被动免疫接种，因为他们接种疫苗后体液反应不足。在移植等待名单（SOTwl）上的患者被排除在该策略之外。目的比较SOT和SOTwl患者COVID-19的住院风险、ICU入院风险和死亡率。方法2020年3月14日至2022年4月13日在Ramón Cajal医院预防内科就诊的患者。估计SOT和SOTwl患者的住院、ICU住院和死亡率的相对风险（RR），并根据年龄、性别和疫苗剂量进行调整。结果共分析1292例患者。SOT患者（n = 1153）年龄较大，与SOTwl患者（n = 139）相比，其住院（RR 0.97, 95% CI 0.57-1.64）、ICU住院（RR 1.74, 95% CI 0.44-6.86）和死亡（RR 0.89, 95% CI 0.45-1.77）的风险相似。结论SOT与SOTwl患者的住院风险、ICU入院风险和死亡风险相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.