Smart Bioelectronics for Real-Time Diagnosis and Therapy of Body Organ Functions

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors Pub Date : 2025-05-01 DOI:10.1021/acssensors.5c00024

Lili Guo, Hin Kiu Lee, Suyoun Oh, Gyan Raj Koirala, Tae-il Kim

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Abstract

Noncommunicable diseases (NCDs) associated with cardiovascular, neurological, and gastrointestinal disorders remain a leading cause of global mortality, sounding the alarm for the urgent need for better diagnostic and therapeutic solutions. Wearable and implantable biointegrated electronics offer a groundbreaking solution, combining real-time, high-resolution monitoring with innovative treatment capabilities tailored to specific organ functions. In this comprehensive review, we focus on the diseases affecting the brain, heart, gastrointestinal organs, bladder, and adrenal gland, along with their associated physiological parameters. Additionally, we provide an overview of the characteristics of these parameters and explore the potential of bioelectronic devices for in situ sensing and therapeutic applications and highlight the recent advancements in their deployment across specific organs. Finally, we analyze the current challenges and prospects of implementing closed-loop feedback control systems in integrated sensor-therapy applications. By emphasizing organ-specific applications and advocating for closed-loop systems, this review highlights the potential of future bioelectronics to address physiological needs and serves as a guide for researchers navigating the interdisciplinary fields of diagnostics, therapeutics, and personalized medicine.

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用于身体器官功能实时诊断和治疗的智能生物电子学

与心血管、神经和胃肠道疾病相关的非传染性疾病仍然是全球死亡的主要原因，这为迫切需要更好的诊断和治疗解决方案敲响了警钟。可穿戴和植入式生物集成电子产品提供了一种突破性的解决方案，将实时、高分辨率监测与针对特定器官功能量身定制的创新治疗能力相结合。在这篇全面的综述中，我们关注影响大脑、心脏、胃肠器官、膀胱和肾上腺的疾病，以及它们相关的生理参数。此外，我们概述了这些参数的特征，并探讨了生物电子器件在原位传感和治疗应用方面的潜力，并强调了它们在特定器官部署方面的最新进展。最后，我们分析了在集成传感器治疗应用中实现闭环反馈控制系统的当前挑战和前景。通过强调器官特异性应用和提倡闭环系统，本综述强调了未来生物电子学在解决生理需求方面的潜力，并为研究人员在诊断、治疗和个性化医疗等跨学科领域的导航提供了指导。

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.