Gut T cell plasticity generates pathogenic TFH cells that promote systemic autoimmunity

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-04-30 DOI:10.1038/s41590-025-02147-1

引用次数: 0

Abstract

Using a fate-mapping autoimmune arthritis mouse model and single-cell RNA sequencing, we identified aberrant T follicular helper (TFH) cells that arise owing to T cell plasticity in the gut and are highly pathogenic. Importantly, the mucosal gene signature of TFH cells also exists in patients with rheumatoid arthritis.

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肠道T细胞可塑性产生致病性TFH细胞，促进全身自身免疫

利用命运定位自身免疫性关节炎小鼠模型和单细胞RNA测序，我们发现了由于肠道T细胞可塑性而产生的异常T滤泡辅助细胞（TFH），并且是高致病性的。重要的是，TFH细胞的粘膜基因特征也存在于类风湿关节炎患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.