Alterations within and between intrinsic connectivity networks in cognitive interference resolution

Abstract

Cognitive interference resolution (CIR) is the process of maintaining goal-directed focus despite the presence of distractions. While CIR has been extensively studied through localized activation analyses, its network-level dynamics remain underexplored with sufficient methodological diversity.

In this study, we investigated the task-modulated intrinsic connectivity networks (ICNs) and their dynamic interactions with detailed subnetwork segmentation during CIR using fMRI data from 27 healthy adults performing the Multi-Source Interference Task (MSIT). We applied high-order group independent component analysis (ICA) to extract ICN subcomponents, followed by task-modulated component identification and dynamic functional connectivity analysis to examine network interactions.

Our results reveal that the dorsal attention network (DAN) and cognitive control network (CCN) show increased activation and connectivity, while the default mode network (DMN) and limbic network exhibit decreased activation and connectivity. Additionally, the visual and cerebellum networks emerge as key intermediaries in CIR, as DAN and CCN strengthen their connectivity with these networks rather than directly interacting with each other. Furthermore, network reconfiguration patterns suggest functional segregation within the somatomotor network and CCN, indicating specialized subcomponent contributions.

These findings provide a granular understanding of ICN activations and dynamic inter-network communication during CIR, offering new insights into the flexible reorganization of brain networks in response to cognitive interference.