Core-shell bimetallic alloyed Pd@Pt nanocubes for synergistic photothermal/chemodynamic infectious wound therapy

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-04-29 DOI:10.1016/j.colsurfa.2025.137075

Heying Li , Jingming Zhai , Qingnan Zhang, Jinghua Li

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引用次数: 0

Abstract

Infections resulting from bacteria resistant to antibiotics represent a significant risk to human health. Therefore, exploring novel and effective antibacterial treatment strategies as substitutes for traditional antibiotics is essential. Here, we developed heterogeneous bimetallic Pd@Pt Cubes with a core-shell structure for near-infrared light-enhanced bacterial infection treatment. Heterogeneous core-shell bimetallic Pd@Pt nanocubes demonstrated remarkable photothermal properties along with peroxidase-mimic activity, promoting the combined interaction between photothermal antibacterial therapy (PTT) and chemodynamic therapy (CDT). As demonstrated in vitro antibacterial tests, Pd@Pt Cubes can effectively eliminate both E. coli and S. aureus, and enhance drug penetration in biofilm by disrupting the biofilm. Furthermore, in vivo antibacterial tests indicated that Pd@Pt Cubes can significantly enhance the repair of tissues in bacterial infection sites. Overall, this study constructed an efficient and multifunctional antibacterial nanoplatform through a rational combination and design, and achieved PTT/CDT bimodal bacterial infection treatment through multiple enhancement strategies.

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核壳双金属合金Pd@Pt纳米立方体用于协同光热/化学动力感染性伤口治疗

对抗生素有耐药性的细菌引起的感染对人类健康构成重大风险。因此，探索新的有效的抗菌治疗策略作为传统抗生素的替代品是至关重要的。在这里，我们开发了具有核壳结构的异质双金属Pd@Pt立方体，用于近红外光增强细菌感染治疗。异质核壳双金属Pd@Pt纳米立方具有显著的光热性能和过氧化物酶模拟活性，促进了光热抗菌治疗（PTT）和化学动力治疗（CDT）的联合相互作用。体外抗菌实验表明，Pd@Pt Cubes可以有效地清除大肠杆菌和金黄色葡萄球菌，并通过破坏生物膜来增强药物在生物膜中的渗透。此外，体内抗菌试验表明Pd@Pt Cubes可以显著增强细菌感染部位的组织修复。总体而言，本研究通过合理组合和设计构建了高效多功能抗菌纳米平台，并通过多种增强策略实现了PTT/CDT双峰细菌感染的治疗。

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.