Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-04-23 DOI:10.1016/j.neuroimage.2025.121238

Kelly A. Duffy , Andrea Wiglesworth , Donovan J. Roediger , Ellery Island , Bryon A. Mueller , Monica Luciana , Bonnie Klimes-Dougan , Kathryn R. Cullen , Mark B. Fiecas

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引用次数: 0

Abstract

Understanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority of developmental neuroscience given the complex interplay of these factors in the onset of psychopathology. Previous research has investigated how these factors relate to static (time-averaged) functional connectivity (FC), but little is known about their relationship with dynamic (time-varying) FC. The present study aimed to investigate the unique and overlapping roles of these factors on dynamic FC in children aged approximately 9 to 14 in the ABCD Study using a sample of 5122 low-motion resting-state scans (from 4136 unique participants). Time-varying correlations in the frontolimbic, default mode, and dorsal and ventral corticostriatal networks, estimated using the Dynamic Conditional Correlations (DCC) method, were used to calculate variability of within- and between-network connectivity and of graph theoretical measures of segregation and integration. We found decreased variability in global efficiency across the age range, and increased variability within the frontolimbic network driven primarily by those assigned female at birth (AFAB). AFAB youth specifically also showed increased variability in several other networks. Controlling for age, both advanced pubertal development and being AFAB were associated with decreased variability in all within- and between-network correlations and increased variability in measures of network segregation. These results potentially suggest advanced brain maturation in AFAB youth, particularly in key networks related to psychopathology, and lay the foundation for future investigations of dynamic FC.

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描述年龄、青春期和性别对儿童期晚期和青春期早期静息状态功能连接变异性的影响

考虑到这些因素在精神病理学发病中的复杂相互作用，了解年龄、青春期发育和出生性别对大脑发育的相对影响是发育神经科学的一个关键优先事项。以前的研究已经研究了这些因素与静态（时间平均）功能连接（FC）的关系，但对它们与动态（时变）功能连接的关系知之甚少。本研究旨在通过5122个低运动静息状态扫描样本（来自4136个单独参与者），研究这些因素在ABCD研究中对9至14岁儿童动态FC的独特和重叠作用。使用动态条件相关性（DCC）方法估计额叶、默认模式、背侧和腹侧皮质纹状体网络的时变相关性，用于计算网络内部和网络之间连通性以及隔离和整合的图理论测量的可变性。我们发现，在整个年龄范围内，整体效率的可变性降低了，而额叶边缘网络的可变性增加了，主要是由那些出生时被指定为女性的人（AFAB）驱动的。AFAB青年在其他几个网络中也特别表现出增加的变异性。在控制年龄的情况下，青春期发育较晚和AFAB与所有网络内部和网络之间相关性的变异性降低以及网络隔离措施的变异性增加有关。这些结果可能表明，AFAB青年的大脑成熟程度更高，特别是在与精神病理相关的关键网络中，并为未来动态FC的研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.