Influences of enteral nutritional enriched with n-3 polyunsaturated fatty acids on postoperative wound infection following gastrointestinal surgery: A meta-analysis

IF 2.4 3区医学 Q2 DERMATOLOGY

Journal of tissue viability Pub Date : 2025-04-28 DOI:10.1016/j.jtv.2025.100919

Ming Zhang , Hui-Juan Xiao , Yue Li, Ping Zheng, Hua-Ying Yan

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引用次数: 0

Abstract

Background and aim

Postoperative wound infections remain a significant challenge in gastrointestinal surgery, with substantial implications for prolonged hospital stays and healthcare costs. Immunonutrition with n-3 polyunsaturated fatty acids (PUFAs) offers potential preventive benefits through modulation of inflammatory responses. This study aimed to explore the impact of enteral nutritional enriched with n-3 PUFAs on wound infection in patients undergoing gastrointestinal surgery.

Methods

A thorough search was carried out, from databases to December 2023, across Cochrane Library, Embase, CNKI, Google Scholar, Wanfang, and PubMed on randomized controlled trials (RCTs) examining the impacts of enteral nutritional enriched with n-3 PUFAs for treatment of patients with gastrointestinal surgery. Two independent researchers conducted literature screening, data extraction, and quality assessments. The primary outcome measures were wound infection and complications. Statistical analysis was conducted in Stata 17.0 and RevMan 5.4 software.

Results

Fifteen RCTs involving 1442 patients who underwent gastrointestinal surgery were included. The analysis revealed the application of enteral nutritional enriched with n-3 PUFAs markedly decreased the occurrence of complications (odds ratio [OR] = 0.56, 95 % confidence intervals [CI]: 0.44–0.71, P < 0.001) and wound infection (OR = 0.68, 95 %CI: 0.47–0.98, P = 0.04) in patients who underwent gastrointestinal surgery.

Conclusions

This study demonstrates that postoperative support with enteral nutritional enriched with n-3 PUFAs can effectively decrease the occurrence of wound infections and postoperative complications following gastrointestinal surgery. These findings suggest that n-3 PUFAs supplementation should be considered as a standard component of perioperative nutritional protocols to improve surgical outcomes in patients undergoing gastrointestinal procedures.

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富含n-3多不饱和脂肪酸的肠内营养对胃肠道手术后伤口感染的影响：一项荟萃分析

背景和目的术后伤口感染仍然是胃肠道手术的重大挑战，对延长住院时间和医疗费用有重大影响。含有n-3多不饱和脂肪酸（PUFAs）的免疫营养通过调节炎症反应提供潜在的预防益处。本研究旨在探讨富含n-3 PUFAs的肠内营养对胃肠手术患者伤口感染的影响。方法从Cochrane Library、Embase、CNKI、b谷歌Scholar、万方、PubMed等数据库中检索截至2023年12月的随机对照试验（RCTs），研究富含n-3 PUFAs的肠内营养对胃肠道手术患者治疗的影响。两位独立研究人员进行了文献筛选、数据提取和质量评估。主要观察指标为伤口感染和并发症。在Stata 17.0和RevMan 5.4软件中进行统计分析。结果纳入15项随机对照试验，共1442例接受胃肠手术的患者。分析显示，应用富含n-3 PUFAs的肠内营养可显著降低并发症的发生(优势比[OR] = 0.56, 95%可信区间[CI]: 0.44-0.71, P <；0.001)和伤口感染（OR = 0.68, 95% CI: 0.47-0.98, P = 0.04）。结论经n-3 PUFAs肠内营养支持可有效减少胃肠道手术后伤口感染和术后并发症的发生。这些发现表明，补充n-3 PUFAs应被视为围手术期营养方案的标准组成部分，以改善胃肠手术患者的手术结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of tissue viability DERMATOLOGY-NURSING

CiteScore

3.80

自引率

16.00%

发文量

110

审稿时长

>12 weeks

期刊介绍： The Journal of Tissue Viability is the official publication of the Tissue Viability Society and is a quarterly journal concerned with all aspects of the occurrence and treatment of wounds, ulcers and pressure sores including patient care, pain, nutrition, wound healing, research, prevention, mobility, social problems and management. The Journal particularly encourages papers covering skin and skin wounds but will consider articles that discuss injury in any tissue. Articles that stress the multi-professional nature of tissue viability are especially welcome. We seek to encourage new authors as well as well-established contributors to the field - one aim of the journal is to enable all participants in tissue viability to share information with colleagues.