Photocatalytic C–H functionalization utilizing acridine−Lewis acid complexes and pyridine N-oxide based HAT catalysts

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-26 DOI:10.1016/j.tet.2025.134683

Jun Luo, Jujhar Singh, Yongming Deng

引用次数: 0

Abstract

Pyridine N-oxides have been well established as a class of potent hydrogen-atom-transfer (HAT) catalysts for C–H functionalization of unactivated alkanes and activated C–H substrates. The combination of acridine derivatives and Lewis acids forms in situ-generated photocatalysts that are able to photo-oxidize pyridine N-oxides to generate N-oxide radicals upon irradiation with visible light. Herein, we described a photocatalytic C–H functionalization utilizing acridine−Lewis acid complexes and pyridine N-oxide based HAT catalysts. The readily available and facilely tunable photocatalytic system of acridine-Lewis acid complexes and pyridine N-oxides enables a broad range of substrates with high reactivities (up to 97 % yield).

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利用吖啶-路易斯酸配合物和吡啶n -氧化物基HAT催化剂光催化C-H功能化

吡啶n-氧化物已被确定为一类有效的氢原子转移（HAT）催化剂，用于非活化烷烃和活化C-H底物的C-H功能化。在可见光照射下，吡啶衍生物和路易斯酸的结合形成了原位生成的光催化剂，能够光氧化吡啶n -氧化物生成n -氧化物自由基。在这里，我们描述了利用吖啶-路易斯酸配合物和吡啶n -氧化物为基础的HAT催化剂光催化C-H功能化。由吖啶-刘易斯酸配合物和吡啶n -氧化物组成的光催化体系易于获得，易于调节，可用于各种具有高反应活性的底物（收率高达97%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.