Forensic and phylogenetic characterization of 24 autosomal STR in the Sindhi population of India

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-05-01 DOI:10.1016/j.genrep.2025.102234

Khushboo Gautam , Chanchal Devnani , Shivani Dixit , Pankaj Shrivastav , Shruti Dasgupta , Madhusudan Reddy Nandineni , Kumarasamy Thangaraj , Rakesh Rawal , Gyaneshwer Chaubey

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引用次数: 0

Abstract

Short Tandem Repeats (STR) genotyping is of utmost importance in forensic casework. Thus, this study, for the first time, explores the forensic profile of the Sindhi population of India, a community with deep historical roots in the Indus Valley Civilization, through the analysis of 24 autosomal short tandem repeat (STR) loci. We found a total of 292 alleles for 24 STRs, and for each locus, the number of alleles ranged from 8 to 22. Out of 24 loci analysed, we obtained the highest genetic diversity for SE33 (0.947) and the lowest for TPOX (0.646) loci. We observed the highest Power of Discrimination (PD) for SE33 (0.988) and the lowest for TPOX (0.79) loci. SE33 locus has the highest number of alleles (36), while the CSF1PO, D5S818, TH01, and TPOX loci have the lowest (6 each). Research has revealed a significant genetic link between the Indian Sindhi population and their ancestral homeland. Based on the present analysis, we conclude that these 24 STR makers used in the present study are highly informative for individual identification, paternity testing, and population genetic studies.

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印度信德人24例常染色体STR的法医学和系统发育特征

短串联重复序列（STR）基因分型在法医案件工作中至关重要。因此，本研究首次通过对24个常染色体短串联重复序列（STR）位点的分析，探索了印度信德人的法医特征，信德人是一个在印度河流域文明中有着深厚历史根源的社区。24个str共有292个等位基因，每个位点的等位基因数在8 ~ 22个之间。在分析的24个位点中，SE33位点的遗传多样性最高（0.947），TPOX位点的遗传多样性最低（0.646）。我们观察到SE33位点的辨别力最高（0.988），TPOX位点的辨别力最低（0.79）。SE33位点等位基因数量最多（36个），CSF1PO、D5S818、TH01和TPOX位点等位基因数量最少（各6个）。研究揭示了印度信德人与其祖先家园之间的重要遗传联系。基于目前的分析，我们得出结论，本研究中使用的这24个STR制造者对个体鉴定，亲子鉴定和群体遗传研究具有很高的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.