Pd-Catalyzed Regioselective Hydroxymethylation of Olefins with HCO2H via Sequential Hydroformylation and Reduction

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-04-29 DOI:10.1021/acs.joc.5c00436

Wenlong Ren, Jinzi Huang, Jintao Ou, Xujian Sheng, Yuan Shi, Ke Huang, Yian Shi

引用次数: 0

Abstract

An effective Pd-catalyzed regioselective hydroxymethylation of olefins with HCO₂H and Ac₂O is described. A variety of primary alcohols can be obtained in up to 94% yield and a >20:1 l:b ratio via sequential hydroformylation and reduction. The reaction is operationally simple with no need for external CO and H₂.

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pd催化烯烃与HCO2H通过顺序氢甲酰化和还原的区域选择性羟甲基化

描述了一种有效的pd催化烯烃与HCO2H和Ac2O的区域选择性羟甲基化反应。通过连续的氢甲酰化和还原，可以得到多种伯醇，收率高达94%，比例为20:1。该反应操作简单，不需要外部CO和H2。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.