Precision nutrition for cardiometabolic diseases

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-04-30 DOI:10.1038/s41591-025-03669-9

Marta Guasch-Ferré, Clemens Wittenbecher, Marie Palmnäs, Orly Ben-Yacov, Ellen E. Blaak, Christina C. Dahm, Tove Fall, Berit L. Heitmann, Tine R. Licht, Marie Löf, Ruth Loos, Chirag J. Patel, Carmelo Quarta, Leanne M. Redman, Eran Segal, Nicola Segata, Michael Snyder, Qi Sun, Deirdre K. Tobias, Frank B. Hu, Paul W. Franks, Rikard Landberg, Jennifer L. Sargent, Jordi Merino

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Abstract

Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that expands the understanding of within- and between-person variability in responses to diet. These studies illustrate the promise of precision nutrition to complement the traditional ‘one size fits all’ dietary guidelines, which, while considering broad life-stage and disease-specific nutritional requirements, often lack the granularity to account fully for individual variations in nutritional needs and dietary responses. Despite these developments, however, considerable challenges remain before precision nutrition can be implemented on a broader scale. This Review examines the current state of precision nutrition research, with a focus on its application to reducing the incidence and burden of cardiometabolic diseases. We critically examine the evidence base, explore the potential benefits and discuss the challenges and opportunities ahead.

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心脏代谢疾病的精准营养

精密营养是一个充满活力和快速发展的科学研究和创新领域，有可能通过改善医疗保健服务和政策来实现健康、社会和经济效益。深度表型技术、数字工具和人工智能的进步使得早期概念验证研究成为可能，这些研究扩大了对饮食反应中人与人之间和人与人之间差异的理解。这些研究表明，精确营养有望补充传统的“一刀切”膳食指南。传统的膳食指南虽然考虑了广泛的生命阶段和特定疾病的营养需求，但往往缺乏充分考虑营养需求和饮食反应的个体差异的粒度。然而，尽管取得了这些进展，但在更广泛地实施精确营养之前，仍存在相当大的挑战。本文综述了精密营养的研究现状，重点介绍了其在降低心血管代谢疾病发病率和减轻疾病负担方面的应用。我们严格审查证据基础，探索潜在的好处，并讨论未来的挑战和机遇。

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.