Determination of 59 Psychotropic Drugs, Including Antipsychotics, Antidepressants, Antiepileptics, Anti-Alcohol Abuse Drugs, Anti-ADHD Drugs, and Their Metabolites in Urine Using LC–MS/MS for Medication Compliance Monitoring

IF 1.8 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Biomedical Chromatography Pub Date : 2025-04-29 DOI:10.1002/bmc.70074

Jeong Eun Kim, Seon Yeong Kim, Jae Chul Cheong, Jin Young Kim

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引用次数: 0

Abstract

Increasing social concern regarding individuals with mental health disorders in the criminal justice system has underscored the need for effective strategies to reduce recidivism. Medication compliance monitoring is a critical approach that ensures adherence to prescribed treatments, facilitating the reintegration of these individuals into society. This study focuses on the development and validation of a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for detecting 59 psychotropic drugs and their metabolites in urine, addressing a significant gap in existing monitoring techniques. Utilizing a dilute-and-shoot approach for urine sample preparation, we established a robust analytical method that demonstrated high sensitivity and precision, with limits of detection ranging from 0.07 to 1.5 ng/mL and correlation coefficients consistently above 0.997. The method was validated through various parameters, including selectivity, stability, and accuracy, ensuring reliable performance in forensic applications. Analysis of urine samples from 248 individuals on probation with mental health conditions confirmed the practicality of the method, identifying 53 psychotropic substances. The LC–MS/MS method was successfully applied for medication compliance monitoring of mentally disordered probationers. Therefore, this analytical method could provide clear evidence for preventing the recurrence of mentally disordered crimes.

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用LC-MS /MS监测尿中59种精神药物（包括抗精神病药、抗抑郁药、抗癫痫药、抗酒精滥用药、抗adhd药）及其代谢物的用药依从性

社会对刑事司法系统中精神健康障碍患者的关注日益增加，这突出表明需要采取有效战略来减少累犯。药物依从性监测是确保遵守规定治疗的关键方法，有助于这些人重新融入社会。本研究的重点是建立和验证液相色谱-串联质谱（LC-MS /MS）检测尿液中59种精神药物及其代谢物的方法，解决现有监测技术的重大空白。采用稀释后注射的方法制备尿样，建立了灵敏度和精密度高的分析方法，检出限为0.07 ~ 1.5 ng/mL，相关系数均在0.997以上。该方法通过各种参数进行了验证，包括选择性、稳定性和准确性，确保了在法医应用中的可靠性能。对248名有精神健康问题的缓刑人员的尿液样本的分析证实了该方法的实用性，鉴定出53种精神药物。LC-MS /MS方法成功应用于精神障碍缓刑犯的用药依从性监测。因此，这种分析方法可以为预防精神障碍犯罪的再次发生提供明确的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Chromatography 生物-分析化学

CiteScore

3.60

自引率

5.60%

发文量

268

审稿时长

2.3 months

期刊介绍： Biomedical Chromatography is devoted to the publication of original papers on the applications of chromatography and allied techniques in the biological and medical sciences. Research papers and review articles cover the methods and techniques relevant to the separation, identification and determination of substances in biochemistry, biotechnology, molecular biology, cell biology, clinical chemistry, pharmacology and related disciplines. These include the analysis of body fluids, cells and tissues, purification of biologically important compounds, pharmaco-kinetics and sequencing methods using HPLC, GC, HPLC-MS, TLC, paper chromatography, affinity chromatography, gel filtration, electrophoresis and related techniques.