CAPA Neuropeptide and Its Receptor in Insects: A Mini Review

Abstract

A neuropeptide, the CAPA, and its cognate receptor have been diversely characterized in different orders of class Insecta. CAPA peptides are synthesized in the abdominal neurohemal system and activate their corresponding receptor, CAPA receptor (CAPA-R), a type of G protein-coupled receptor (GPCR), to initiate cellular signals for diverse physiological functions in insects. Activation of the CAPA-R in Malpighian tubules results in ion-water homeostasis via antidiuresis in the majority of insect species; however, diuresis and myotropic activities are also known to result. Antidiuretic activity of CAPA peptides has been reported from mosquitoes, assassin bugs, spotted wing drosophila, and more; hence, this group of peptides also holds importance as potential targets when it comes to medical and agricultural entomology. GPCRs form a diverse family of cell membrane receptors responsible for signal transduction across the cell membrane in humans as well as in insects. With the advances in knowledge of human GPCRs, their physiological functions in agriculturally important insects have offered an opportunity for designing and implementing GPCR-targeting compounds in integrated pest management programs. In this review, we present a comprehensive view on physiological factors and peptides responsible for the diuresis/anti-diuresis in insects with special reference to the CAPA peptide-receptor interaction. The major focus is on the role of CAPA peptides in fluid and energy homeostasis, stress tolerance, muscle functioning, regulation of reproduction, and diapause-related processes. We end by outlining the significance of insect excretion with respect to the capa-r gene silencing and pest management.