Muge Akinci, Pablo Aguilar-Domínguez, Eleni Palpatzis, Mahnaz Shekari, Marina García-Prat, Carme Deulofeu, Karine Fauria, Judith García-Aymerich, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Eider M. Arenaza-Urquijo, for the ALFA study
{"title":"Physical activity changes during midlife link to brain integrity and amyloid burden","authors":"Muge Akinci, Pablo Aguilar-Domínguez, Eleni Palpatzis, Mahnaz Shekari, Marina García-Prat, Carme Deulofeu, Karine Fauria, Judith García-Aymerich, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Eider M. Arenaza-Urquijo, for the ALFA study","doi":"10.1002/alz.70007","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Evidence suggests that midlife physical activity may reduce Alzheimer's disease (AD) risk. In at-risk individuals, we investigated midlife physical activity changes in relation to AD-related pathologies.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We included 337 cognitively unimpaired adults with baseline and follow-up physical activity evaluations within 4.07 ± 0.84 years. We performed multiple regressions considering follow-up amyloid-PET burden and MRI-based medial temporal lobe cortical thickness as outcomes. Independent variables encompassed changes in adherence to World Health Organization (WHO)-recommended physical activity levels, activity amounts, and sedentary behavior (no activity reported).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Remaining sedentary was associated with lower cortical thickness compared to doing limited physical activity, maintaining adherence, or becoming adherent to WHO recommendations. Becoming adherent to recommendations was linked to lower amyloid burden compared to becoming non-adherent. Increased activity amounts showed a dose-dependent association with lower amyloid burden.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Increasing physical activity and new adherence to WHO recommendations could be key objectives for preventive strategies during midlife.</p>\n </section>\n \n <section>\n \n <h3> CLINICAL TRIAL REGISTRATION INFORMATION</h3>\n \n <p>Registered at Clinicaltrials.gov (identifier: NCT02485730).</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Boosting physical activity in midlife may have beneficial effects in preclinical AD.</li>\n \n <li>Physical activity increases relate to lower Aβ burden in a dose-dependent manner.</li>\n \n <li>Remaining sedentary links to lower cortical thickness in AD-vulnerable structures.</li>\n \n <li>New adherence to WHO-recommended physical activity levels may enhance brain health.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70007","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70007","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
INTRODUCTION
Evidence suggests that midlife physical activity may reduce Alzheimer's disease (AD) risk. In at-risk individuals, we investigated midlife physical activity changes in relation to AD-related pathologies.
METHODS
We included 337 cognitively unimpaired adults with baseline and follow-up physical activity evaluations within 4.07 ± 0.84 years. We performed multiple regressions considering follow-up amyloid-PET burden and MRI-based medial temporal lobe cortical thickness as outcomes. Independent variables encompassed changes in adherence to World Health Organization (WHO)-recommended physical activity levels, activity amounts, and sedentary behavior (no activity reported).
RESULTS
Remaining sedentary was associated with lower cortical thickness compared to doing limited physical activity, maintaining adherence, or becoming adherent to WHO recommendations. Becoming adherent to recommendations was linked to lower amyloid burden compared to becoming non-adherent. Increased activity amounts showed a dose-dependent association with lower amyloid burden.
DISCUSSION
Increasing physical activity and new adherence to WHO recommendations could be key objectives for preventive strategies during midlife.
CLINICAL TRIAL REGISTRATION INFORMATION
Registered at Clinicaltrials.gov (identifier: NCT02485730).
Highlights
Boosting physical activity in midlife may have beneficial effects in preclinical AD.
Physical activity increases relate to lower Aβ burden in a dose-dependent manner.
Remaining sedentary links to lower cortical thickness in AD-vulnerable structures.
New adherence to WHO-recommended physical activity levels may enhance brain health.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
