The Role of Bile Acid in Immune-Mediated Skin Diseases

IF 3.5 3区医学 Q1 DERMATOLOGY

Experimental Dermatology Pub Date : 2025-04-29 DOI:10.1111/exd.70108

Huike Ma, Ruonan Li, Baoquan Qu, Yuchen Liu, Ping Li, Jingxia Zhao

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Abstract

Immune-mediated skin disorders arise from dysfunctional immune responses, instigating inflammatory dermatoses and a reduced quality of life. The complex pathogenesis likely involves genetic risks, environmental triggers and aberrant immune activation. An emerging body of evidence suggests that bile acid disturbances may critically promote immune pathology in certain skin conditions. Bile acids synthesised from cholesterol regulate nutrient metabolism and immune cell function via nuclear receptors and G protein-coupled receptors (GPCRs). Altered bile acid profiles and receptor expression have been identified in psoriasis, atopic dermatitis (AD) and autoimmune blistering diseases. Disruptions in bile acid signalling affect the inflammatory and metabolic pathways linked to these disorders. Targeting components of the bile acid axis represents a promising therapeutic strategy. This review elucidates the intricate links between bile acid homeostasis and immune dysfunction in inflammatory skin diseases, synthesising evidence that targeting bile acid pathways may unlock innovative therapeutic avenues. This study compiles clinical and experimental data revealing disrupted bile acid signalling and composition in various immune-mediated dermatoses, highlighting the emerging significance of bile acids in cutaneous immune regulation.

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胆汁酸在免疫介导的皮肤病中的作用

免疫介导的皮肤疾病源于功能失调的免疫反应，引发炎症性皮肤病和生活质量下降。复杂的发病机制可能涉及遗传风险、环境触发和异常免疫激活。越来越多的证据表明，胆汁酸紊乱可能会严重促进某些皮肤状况的免疫病理。由胆固醇合成的胆汁酸通过核受体和G蛋白偶联受体（gpcr）调节营养代谢和免疫细胞功能。胆汁酸谱和受体表达的改变已经在牛皮癣、特应性皮炎（AD）和自身免疫性水疱疾病中被发现。胆汁酸信号的中断影响与这些疾病相关的炎症和代谢途径。靶向胆汁酸轴的成分是一种很有前途的治疗策略。这篇综述阐明了炎症性皮肤病中胆汁酸稳态与免疫功能障碍之间的复杂联系，综合证据表明靶向胆汁酸途径可能开启创新的治疗途径。本研究收集了临床和实验数据，揭示了各种免疫介导的皮肤病中胆汁酸信号和成分的破坏，强调了胆汁酸在皮肤免疫调节中的新意义。

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来源期刊

Experimental Dermatology 医学-皮肤病学

CiteScore

6.70

自引率

5.60%

发文量

201

审稿时长

2 months

期刊介绍： Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.