Evaluation of Treatment Response and Survival Outcomes in Anaplastic Thyroid Cancer Patients Following Surgery With and Without Other Treatment Modalities: A Systematic Review

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-04-30 DOI:10.1002/hsr2.70710

Hossein Negahban, Nazila Heidari, Amirhossein Heidari, Yekta Ghane, Mohammad Shirkhoda, Amirmohsen Jalaeefar

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Abstract

Background and Aims

Anaplastic thyroid carcinoma (ATC) is a rare type of malignancy ranking among the most aggressive diseases globally, with an extremely poor prognosis. No optimal standardized treatment has been established yet to promote ATC's prognosis and increase the patients' median survival. We aim to assess the effectiveness of surgery alone or combined with other treatment approaches for ATC patients.

Methods

PubMed, Web of Science, and Scopus databases were systematically searched until June 1st, 2023. Study selection was limited to English retrospective studies. A citation search was also performed for the final articles that were included. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews and meta-analyses.

Results

During our search, we came to include 56 articles containing 16,246 patients suffering from ATC. We assessed the overall survival by treatment method and stage, emphasizing surgery's role. The most common efficacious treatment option in patients with resectable cancer is a combination of surgery with adjuvant chemoradiotherapy. However, surgery for stage IVC patients is controversial. Additionally, surgery and multimodality treatment can be affected by patients' characteristics, such as tumor size.

Conclusions

Stage IVA and IVB resectable cancers may benefit from the combination of surgery and adjuvant therapies. However, the effectiveness of invasive treatments and the selection of appropriate adjuvant therapy options for IVC-stage patients are still controversial.

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评估甲状腺间变性癌患者手术后的治疗反应和生存结果，有无其他治疗方式：一项系统综述

背景与目的间变性甲状腺癌（ATC）是一种罕见的恶性肿瘤，是全球最具侵袭性的疾病之一，预后极差。目前还没有最佳的标准化治疗方法来改善ATC的预后并提高患者的中位生存期。我们的目的是评估单独手术或联合其他治疗方法对ATC患者的有效性。方法系统检索PubMed、Web of Science、Scopus数据库至2023年6月1日。研究选择仅限于英语回顾性研究。对最终纳入的文章也进行了引文搜索。本研究遵循系统评价和元分析首选报告项目（PRISMA）指南进行系统评价和元分析。在我们的检索中，我们纳入了56篇文章，共16,246例ATC患者。我们根据治疗方法和分期评估总生存率，强调手术的作用。在可切除的癌症患者中，最常见的有效治疗选择是手术与辅助放化疗的结合。然而，对IVC期患者进行手术是有争议的。此外，手术和多模式治疗可能受到患者特征（如肿瘤大小）的影响。结论IVA期和IVB期可切除肿瘤可从手术和辅助治疗相结合中获益。然而，侵入性治疗的有效性以及对ivc期患者选择合适的辅助治疗方案仍存在争议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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