{"title":"The Reliability of CBCT to Assess Quality of Augmented Bone After Lateral Sinus Floor Elevation With Xenografts: A Retrospective Analysis","authors":"Xixuan Wang, Wenyan Zhao, Menglin Liao, Yunfei Liu, Chengzhe Ban, Gang Fu, Qingqing Wu","doi":"10.1111/cid.70029","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objetives</h3>\n \n <p>This study aimed to explore the reliability of cone beam computed tomography (CBCT) in evaluating the quality of augmented bone after lateral sinus floor elevation (LSFE) with xenografts.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Thirty-six patients with lost maxillary molars were included, with half of whom received LSFE with xenografts and staged implant placement, and the other half showed no vertical bone defects and underwent implant placement directly. A total of 36 implants were included, with 18 implants in each group. A CBCT exam was taken before implant placement to acquire data on mineral quality at the future implant site, including bone mineral density (BMD), various microstructure indices, and gray values (GVs) within different threshold ranges. Augmented bone biopsies were collected during implant preparation. The microstructure indices and histological characteristics of the biopsies were evaluated by micro computed tomography (μCT) and histological staining. An implant-oriented volume of interest for CBCT analysis was established to co-locate the CBCT-measured data and the biopsy-related data using 3DSlicer. A Spearman rank correlation test was used to analyze the relationship between CBCT-measured data and the biopsy-related data.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>μCT-measured microstructure indices of the augmented bone (BV/TV and Tb.Th) were significantly correlated with new bone area (BV/TV, <i>p</i> = 0.035, <i>r</i> = 0.498; Tb.Th, <i>p</i> = 0.027, <i>r</i> = 0.520). No correlation was found between the CBCT-measured and μCT-measured microstructure indices. CBCT-measured BMD and microstructure indices hardly showed any correlation with histological indices (<i>p</i> > 0.05). When the threshold was set from 0 to 50, the mean GVs were significantly, positively correlated with new bone area (<i>p</i> = 0.041, <i>r</i> = 0.486), and bone substitute area was positively correlated to the mean GVs of higher threshold (range 60–255, <i>p</i> = 0.048, <i>r</i> = 0.472; range 70–255, <i>p</i> = 0.009, <i>r</i> = 0.593).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>CBCT without bone substitute segmentation was not reliable for evaluating the quality of xenogenic augmented bone after LSFE. The influence of the xenogenic substitute on CBCT analysis can be reduced by setting a low GV threshold. The bone substitute segmentation strategy may present a new way to increase the reliability of CBCT in evaluating xenogenic augmented bone.</p>\n </section>\n </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 3","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Implant Dentistry and Related Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cid.70029","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Objetives
This study aimed to explore the reliability of cone beam computed tomography (CBCT) in evaluating the quality of augmented bone after lateral sinus floor elevation (LSFE) with xenografts.
Materials and Methods
Thirty-six patients with lost maxillary molars were included, with half of whom received LSFE with xenografts and staged implant placement, and the other half showed no vertical bone defects and underwent implant placement directly. A total of 36 implants were included, with 18 implants in each group. A CBCT exam was taken before implant placement to acquire data on mineral quality at the future implant site, including bone mineral density (BMD), various microstructure indices, and gray values (GVs) within different threshold ranges. Augmented bone biopsies were collected during implant preparation. The microstructure indices and histological characteristics of the biopsies were evaluated by micro computed tomography (μCT) and histological staining. An implant-oriented volume of interest for CBCT analysis was established to co-locate the CBCT-measured data and the biopsy-related data using 3DSlicer. A Spearman rank correlation test was used to analyze the relationship between CBCT-measured data and the biopsy-related data.
Results
μCT-measured microstructure indices of the augmented bone (BV/TV and Tb.Th) were significantly correlated with new bone area (BV/TV, p = 0.035, r = 0.498; Tb.Th, p = 0.027, r = 0.520). No correlation was found between the CBCT-measured and μCT-measured microstructure indices. CBCT-measured BMD and microstructure indices hardly showed any correlation with histological indices (p > 0.05). When the threshold was set from 0 to 50, the mean GVs were significantly, positively correlated with new bone area (p = 0.041, r = 0.486), and bone substitute area was positively correlated to the mean GVs of higher threshold (range 60–255, p = 0.048, r = 0.472; range 70–255, p = 0.009, r = 0.593).
Conclusions
CBCT without bone substitute segmentation was not reliable for evaluating the quality of xenogenic augmented bone after LSFE. The influence of the xenogenic substitute on CBCT analysis can be reduced by setting a low GV threshold. The bone substitute segmentation strategy may present a new way to increase the reliability of CBCT in evaluating xenogenic augmented bone.
期刊介绍:
The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal.
The range of topics covered by the journals will include but be not limited to:
New scientific developments relating to bone
Implant surfaces and their relationship to the surrounding tissues
Computer aided implant designs
Computer aided prosthetic designs
Immediate implant loading
Immediate implant placement
Materials relating to bone induction and conduction
New surgical methods relating to implant placement
New materials and methods relating to implant restorations
Methods for determining implant stability
A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.