EPR analysis and spectral deconvolution of alanine dosimetric properties

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-03-22 DOI:10.1007/s10967-025-10040-2

Fatna Zahiri, Mohammed Mikou, Abdoul Karim Mamadou Saidou, Ayoub Belahmar, Redouane El Baydaoui

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Abstract

Precise dose monitoring in radiotherapy is essential to ensure treatment efficacy and the protection of healthy tissues. Although the Alanine/EPR dosimetry system has demonstrated dosimetric properties, further analysis of this dosimetry system, taking into account the characteristics of the different contributions to the EPR spectrum of irradiated alanine, will be important in determining the system's performance and ensuring its reliability for dosimetric applications in radiotherapy and hadrontherapy. In this work, we used the deconvolution method, based on the Levenberg–Marquardt algorithm, to determine the contributions constituting the irradiated alanine spectrum. Fourteen contributions were revealed. Analysis of the comportment of these contributions as a function of irradiation dose and post-irradiation storage time revealed quasi-linear evolution according to irradiation dose, and good stability of the produced free radicals during the post-irradiation storage period. This result approves the potential application of the Alanine/EPR system for dose control in radiotherapy.

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丙氨酸剂量学性质的EPR分析和光谱反褶积

放射治疗中精确的剂量监测对保证治疗效果和保护健康组织至关重要。虽然丙氨酸/EPR剂量学系统已经证明了剂量学特性，但考虑到辐照丙氨酸对EPR光谱的不同贡献的特征，对该剂量学系统的进一步分析对于确定系统的性能和确保其在放射治疗和强子疗法中剂量学应用的可靠性将是重要的。在这项工作中，我们使用了基于Levenberg-Marquardt算法的反卷积方法来确定构成辐照丙氨酸谱的贡献。14项贡献被披露。分析这些贡献与辐照剂量和辐照后贮存时间的关系，发现自由基随辐照剂量呈准线性变化，在辐照后贮存期间产生的自由基具有良好的稳定性。这一结果证实了丙氨酸/EPR系统在放射治疗剂量控制中的潜在应用。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.