{"title":"Advances in PET imaging of fibroblast activating protein inhibitors for the diagnosis of common malignant tumors","authors":"Wenfang Liao, Fei Chen, Bao Zhu","doi":"10.1007/s10967-025-10056-8","DOIUrl":null,"url":null,"abstract":"<div><p>Fibroblast activation protein (FAP) is highly expressed in activated fibroblasts by tumor stroma, tumor cells of sarcomas, and granulation tissues, especially in cancers of epithelial origin. However, it is lowly expressed or even not expressed in normal cells. Fibroblast activation protein inhibitor (FAP inhibitor, FAPI) has a high affinity and specificity for FAP, and significant advances in FAP in nuclear medicine since 2018 have been facilitated by the application of nuclide-labeled FAPI for clinical tumor imaging. FAPI imaging is gradually becoming an important imaging agent in the diagnosis of oncological diseases, and this review summarizes the existing literature on FAPI PET/CT imaging for the diagnosis of various malignant diseases.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"334 4","pages":"2557 - 2566"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radioanalytical and Nuclear Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10967-025-10056-8","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Fibroblast activation protein (FAP) is highly expressed in activated fibroblasts by tumor stroma, tumor cells of sarcomas, and granulation tissues, especially in cancers of epithelial origin. However, it is lowly expressed or even not expressed in normal cells. Fibroblast activation protein inhibitor (FAP inhibitor, FAPI) has a high affinity and specificity for FAP, and significant advances in FAP in nuclear medicine since 2018 have been facilitated by the application of nuclide-labeled FAPI for clinical tumor imaging. FAPI imaging is gradually becoming an important imaging agent in the diagnosis of oncological diseases, and this review summarizes the existing literature on FAPI PET/CT imaging for the diagnosis of various malignant diseases.
期刊介绍：
An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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