{"title":"Production of therapeutic radionuclides for bone-seeking radiopharmaceuticals to meet clinical exigency and academic research","authors":"Ashutosh Dash, Tapas Das","doi":"10.1007/s10967-025-10025-1","DOIUrl":null,"url":null,"abstract":"<div><p>This review offers a comprehensive and insightful overview of the production of therapeutic radionuclides (<sup>32</sup>P, <sup>89</sup>Sr, <sup>117m</sup>Sn, <sup>153</sup>Sm, <sup>166</sup>Ho, <sup>186</sup>Re, <sup>188</sup>Re, <sup>177</sup>Lu and <sup>223</sup>Ra), which are essential for developing bone-targeting radiopharmaceuticals. These radionuclides are critical not only in the early stages of radiopharmaceutical development but also in ensuring their continued success, reliability, and progress. The manuscript highlights recent innovations and trends in the field, addressing significant challenges and emerging opportunities. It also examines the regulatory environment and emphasizes the growing role of automation in enhancing the production process.</p></div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"334 4","pages":"2591 - 2611"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10967-025-10025-1.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radioanalytical and Nuclear Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10967-025-10025-1","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This review offers a comprehensive and insightful overview of the production of therapeutic radionuclides (32P, 89Sr, 117mSn, 153Sm, 166Ho, 186Re, 188Re, 177Lu and 223Ra), which are essential for developing bone-targeting radiopharmaceuticals. These radionuclides are critical not only in the early stages of radiopharmaceutical development but also in ensuring their continued success, reliability, and progress. The manuscript highlights recent innovations and trends in the field, addressing significant challenges and emerging opportunities. It also examines the regulatory environment and emphasizes the growing role of automation in enhancing the production process.
期刊介绍:
An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.