Glycosyltransferases: Pioneering roles in agriculture and medicine

Abstract

Glycosyltransferases (GTs) belong to a diverse family of enzymes that catalyze the transfer of sugar moieties from activated donor sugars to specific acceptors, thus playing a crucial roles in various biological processes. This review explores the pioneering roles of uridine diphosphate-dependent GTs (UGTs), which use uridine diphosphate glucose as donors. UGTs have also been extensively studied in agricultural and medical fields, emphasizing their potential to revolutionize these sectors. In the agricultural sector, the genetic engineering of UGTs has demonstrate potential in developing crops with enhanced stress tolerance, regulated plant development, and increased resistance to pests and diseases. These advancements not only contribute to sustainable farming practices but also address global food security challenges by facilitating the production of more resilient plant varieties. Furthermore, UGTs facilitate the synthesis of complex carbohydrates and glycoconjugates in plants, which are critical for developing drugs and therapeutic strategies targeting various ailments, including cancer and infectious diseases. Thus, this review explored the functions and synthesis methods of flavonoid glycosides, terpenoid glycosides, and polyketosides in detail. Moreover, owing to the functional diversity of UGTs, numerous research methods were reviewed, and novel, more valuable UGTs will be obtained. In summary, this study synthesizes the current research findings and discusses future perspectives to underscore the transgenic technology and synthetic biological impact of UGTs on agriculture and medicine and bridge the gap between fundamental science and practical applications.