Increased cerebral hemodynamics during the interictal period of migraine and the association with migraine features

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2025-03-28 DOI:10.1016/j.crad.2025.106918

Y. Liu , A. Sun , Y. Zhang , B. Wang , X. Kuang , F. Dai , H. Wang , J. Ding , X. Wang

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引用次数: 0

Abstract

Aim

To detect cerebral hemodynamic changes in migraine’s interictal period using 4D flow magnetic resonance imaging (MRI) and explore the relationships between altered hemodynamics and migraine features.

Materials and Methods

Twenty-five patients (29 ± 4 years, 22 female) with migraine in the interictal period and twenty-five healthy controls (28 ± 4 years, 20 female) were consecutively enrolled. Migraine features including frequency, duration of migraine history, pain side and degree were collected in migraineurs. 4D flow MRI scan was performed for all subjects. Cross-sectional area, peak systolic through-plane velocity (PSV), average through-plane velocity (V_avg), average blood flow rate (Flow_avg), and average wall shear stress (WSS_avg) in the bilateral middle cerebral artery (MCA) and the posterior cerebral artery (PCA) were measured. Pulsatility index (PI) was calculated from the maximum, minimum and average blood flow velocity. The hemodynamic differences of MCA and PCA in migraineurs and controls were investigated. The relationships between hemodynamic changes and migraine features were further explored.

Results

Increased PSV, V_avg and Flow_avg in the MCA, as well as elevated V_avg, Flow_avg and WSS_avg in the PCA, were found among migraine patients. Flow_avg of PCA was significantly correlated with the duration of migraine history (r = 0.46, P = 0.02).

Conclusion

Cerebral hemodynamics is significantly elevated in migraineurs during the interictal period of migraine. Notably, the Flow_avg in the PCA is associated with the duration of migraine history.

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偏头痛发作间期脑血流动力学增高及其与偏头痛特征的关系

目的应用4D血流磁共振成像（MRI）检测偏头痛发作间期脑血流动力学改变，探讨血流动力学改变与偏头痛特征的关系。材料与方法连续入选25例偏头痛患者（29±4岁，女性22例）和25例健康对照（28±4岁，女性20例）。收集偏头痛患者的偏头痛特征，包括频率、持续时间、疼痛侧面和程度。所有受试者均行4D血流MRI扫描。测量双侧大脑中动脉（MCA）和大脑后动脉（PCA）的横截面积、峰值收缩过面速度（PSV）、平均过面速度（Vavg）、平均血流量（Flowavg）和平均壁剪应力（WSSavg）。脉搏指数（PI）由最大、最小和平均血流速度计算。研究偏头痛患者和对照组MCA和PCA血流动力学的差异。进一步探讨血流动力学变化与偏头痛特征之间的关系。结果偏头痛患者MCA的PSV、Vavg和Flowavg升高，PCA的Vavg、Flowavg和WSSavg升高。PCA流量与偏头痛病史持续时间显著相关（r = 0.46, P = 0.02）。结论偏头痛患者在偏头痛发作间期脑血流动力学明显升高。值得注意的是，PCA中的Flowavg与偏头痛病史的持续时间有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.