Synthesis of Bicyclic Ortho-Amino Carbonitriles Catalyzed by [BMIM]Ac Ionic Liquid: A Green Chemistry Approach

Abstract

A task-specific ionic liquid, 1-butyl-3-methylimidazolium acetate ([BMIM]Ac), has been demonstrated as an efficient and sustainable catalyst for the synthesis of bicyclic ortho-amino carbonitrile derivatives under ambient conditions. The key advantage of this protocol lies in the use of a mild basic ionic liquid, which effectively regulates the reaction, preventing side product formation, and ensuring a direct and selective transformation. Additionally, this method offers several benefits, including high product yields, short reaction times, and the recyclability of the ionic liquid, making it a cost-effective and environmentally friendly approach. Furthermore, a detailed reaction mechanism has been proposed to provide insight into the catalytic process. Green metrics analysis has also been carried out to assess environmental effect and sustainability of this protocol.