High-Frequency Oscillations in Self-Limited Epilepsy With Centrotemporal Spikes: Potential Predictors of Attention Deficit Hyperactivity Disorder?

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-04-29 DOI:10.1002/jdn.70020

Pinar Ozkan Kart, Cihad Özdemir, Temel Kayikcioglu, Ali Cansu

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Abstract

Objective

The aim of this study was to examine the possible effect of HFOs detected in children with SeLECTS, who have rolandic spikes with or without ADHD, in predicting cognitive comorbidities with the fully automatic ripple detector program we developed.

Methods

A total of 40 patients diagnosed with SeLECTS with at least a 1-year follow-up were included in this study. The patients were divided into two groups: those diagnosed with SeLECTS only and those diagnosed with SeLECTS+ADHD. For ripple detection, EEG data recorded for at least 10 min during non-REM stage 2 sleep with a sampling frequency of 2000 Hz was analysed in the MATLAB environment. After the data in each channel was filtered at 80–200 Hz, ripple detection was made with the fully automatically developed ripple detector program.

Results

At least one ripple was detected in 29 of 40 patients (72.5%). The total number of spikes in both groups had a mean of 1435.8 ± 1626.9 (5–6183). The number of spikes in the rolandic region was found to be statistically significantly higher in the SeLECTS+ADHD group (p = 0.042). The total number of ripples in both groups was the mean: 9.5 ± 26.5 (0–158). The highest ripples count was detected in a patient in the SeLECTS+ADHD group; 158 ripples were counted, and the ripple distribution was found to be 33 ripples in the centrotemporal region and 125 ripples in the frontal region. The ripple of number (p = 0.009) and ripple ratio in the ‘Fz-Cz’ electrode were found to be statistically significantly higher in the SeLECTS + ADHD group (p = 0.009, p = 0.019, respectively).

Significance

Our study showed that the presence of interictal scalp HFOs has the effect of predicting neurocognitive comorbidities. We think that ripple analysis with the can be used as a potential biomarker to predict neurocognitive comorbidities.

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伴有中央颞叶尖峰的自限性癫痫的高频振荡：注意缺陷多动障碍的潜在预测因子？

目的：本研究的目的是研究我们开发的全自动纹波检测器程序在伴有或不伴有ADHD的有roland尖峰的select儿童中检测到的hfo在预测认知合并症中的可能作用。方法本研究共纳入40例确诊为select的患者，随访时间至少1年。将患者分为两组：仅诊断为select和诊断为select +ADHD的患者。对于纹波检测，在MATLAB环境中分析采样频率为2000 Hz的非快速眼动阶段2睡眠期间记录的至少10分钟的脑电图数据。在每个通道的数据在80 - 200hz下滤波后，使用全自动开发的纹波检测器程序进行纹波检测。结果40例患者中29例（72.5%）至少检出1个纹波。两组总棘突数平均值为1435.8±1626.9（5-6183）。在select +ADHD组中，roland区域的尖峰数量有统计学意义上的显著增加（p = 0.042）。两组的波纹总数为平均值：9.5±26.5（0-158）。在select +ADHD组的患者中检测到最高的波纹计数；158个波纹被计数，波纹分布发现33个波纹在中央颞叶区，125个波纹在额叶区。select + ADHD组“Fz-Cz”电极的纹波数（p = 0.009）和纹波率（p = 0.019）显著高于对照组（p = 0.009, p = 0.019）。我们的研究表明，头皮内HFOs的存在具有预测神经认知合并症的作用。我们认为波纹分析可以作为一种潜在的生物标志物来预测神经认知合并症。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.