Risk Factors, Pathological Changes, and Potential Treatment of Diabetes-Associated Cognitive Dysfunction

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2025-04-28 DOI:10.1111/1753-0407.70089

Xiaoyu Meng, Haiyang Du, Danpei Li, Yaming Guo, Peiqiong Luo, Limeng Pan, Ranran Kan, Peng Yu, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Wenjun Li, Yan Yang, Xuefeng Yu

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Abstract

Background

Diabetes is a prevalent public health issue worldwide, and the cognitive dysfunction and subsequent dementia caused by it seriously affect the quality of life of patients.

Methods

Recent studies were reviewed to provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for diabetes-related cognitive dysfunction (DACD).

Results

Several risk factors contribute to DACD, including hyperglycemia, hypoglycemia, blood sugar fluctuations, hyperinsulinemia, aging, and others. Among them, modifiable risk factors for DACD include blood glucose control, physical activity, diet, smoking, and hypertension management, while non-modifiable risk factors include age, genetic predisposition, sex, and duration of diabetes. At the present, the pathogenesis of DACD mainly includes insulin resistance, neuroinflammation, vascular disorders, oxidative stress, and neurotransmitter disorders.

Conclusions

In this review, we provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for DACD, providing information from multiple perspectives for its prevention and management.

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糖尿病相关认知功能障碍的危险因素、病理改变和潜在治疗

糖尿病是世界范围内普遍存在的公共卫生问题，其导致的认知功能障碍及随后的痴呆严重影响患者的生活质量。方法对近年来糖尿病相关认知功能障碍（daca）的危险因素、发病机制、病理变化及药物治疗进行综述。结果高血糖、低血糖、血糖波动、高胰岛素血症、衰老等多种危险因素可导致daca的发生。其中，daca可改变的危险因素包括血糖控制、身体活动、饮食、吸烟和高血压管理，而不可改变的危险因素包括年龄、遗传易感性、性别和糖尿病病程。目前，daca的发病机制主要包括胰岛素抵抗、神经炎症、血管紊乱、氧化应激、神经递质紊乱等。本文就daca的危险因素、发病机制、病理变化及潜在的药物治疗进行综述，为daca的预防和治疗提供多角度的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.