Metal/heteroatom-doped carbon-based hybrid material as the matrix for rapid and high-throughput identification of phthalate esters in complex samples by laser desorption/ionization

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-04-29 DOI:10.1007/s00604-025-07124-x

Luyan Meng, Baichun Wang, Yijia Rong, Shun Zhang, Ting Cai, Chuan-Fan Ding, Yinghua Yan

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引用次数: 0

Abstract

A novel matrix of metal particles and metal oxides modified N-doped multi-walled carbon nanotubes (N-MWCNTs/AuNPs/Co₃O₄) is introduced for the rapid detection of phthalate esters (PAEs) using surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). By leveraging the synergistic effects of metal/heteroatom-doped carbon-based components, this innovative hybrid material demonstrated exceptional ionization efficiency for PAEs. Specifically, it enables the detection of bis(2-ethylhexyl) phthalate (DEHP) at concentrations as low as of 1 µg·mL⁻¹. Moreover, the N-MWCNTs/AuNPs/Co₃O₄ composite not only surpassed conventional organic matrices in terms of ionization efficiency and reproducibility, but also facilitated the effective enrichment of PAEs, achieving an enrichment efficiency range from 94.1% ± 5.8% to 98.2% ± 2.3%. Furthermore, this method was successfully applied to detect DEHP in human serum and urine samples, with urinary DEHP concentrations estimated ranging from 29.2 to 38.4 ng·mL⁻¹. This approach represents a promising strategy for high-throughput PAE detection, offering significant potential for applications in environmental and biomedical analysis.

Graphical abstract

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金属/杂原子掺杂碳基杂化材料作为基体，用于激光解吸/电离快速高通量鉴定复杂样品中的邻苯二甲酸酯

介绍了一种新型的金属颗粒和金属氧化物修饰的n掺杂多壁碳纳米管（N-MWCNTs/AuNPs/Co3O4）基质，用于表面辅助激光解吸/电离质谱（SALDI-MS）快速检测邻苯二甲酸酯（PAEs）。通过利用金属/杂原子掺杂碳基组分的协同效应，这种创新的杂化材料表现出卓越的PAEs电离效率。具体来说，它可以检测浓度低至1 μ g·mL的邻苯二甲酸二酯（2-乙基己基）毒血症。此外，N-MWCNTs/AuNPs/Co3O4复合材料不仅在电离效率和再现性方面优于传统的有机基质，而且有利于PAEs的有效富集，富集效率在94.1%±5.8% ~ 98.2%±2.3%之间。此外，该方法还成功地用于检测人血清和尿液样本中的DEHP，尿中DEHP的浓度估计在29.2至38.4 ng·mL毒血症（毒血症）之间。这种方法代表了一种有前途的高通量PAE检测策略，为环境和生物医学分析提供了巨大的应用潜力。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.