N,N′,N″-Trisubstituted hexahydro-1,3,5-triazine-based synthesis of mono- and diphosphorus-containing amino acids

Abstract

Convenient syntheses of mono- and diphosphorus-containing amino acid derivatives based on 1,3,5-[ω-(alkoxycarbonyl)alkyl]hexahydro-1,3,5-triazines have been developed. The reaction of PH acids with readily available hexahydro-1,3,5-triazines and N-substituted bis(alkoxymethyl)amines obtained therefrom gives new mono- and diphosphorus-substituted amino acids containing P(O)CH₂NH and P(O)CH₂NCH₂P(O) units together with glycine, β-alanine and γ-aminobutyric acid residues. The resulting compounds are of interest as promising biologically active substances, effective extractants, and water-soluble polydentate ligands.