{"title":"Determination of the Effects of Surfactants and Cyclodextrins as Co-solvent on the Solubility of Poorly Water-Soluble Flavonoid Naringin","authors":"Hiroyuki Matsuda, Masahiro Kosuge, Rena Yoshimura, Yuma Naito, Tomoya Tsuji, Kiyofumi Kurihara, Katsumi Tochigi","doi":"10.1007/s10953-025-01442-7","DOIUrl":null,"url":null,"abstract":"<div><p>The aim of this work is to experimentally determine co-solvent effects on the solubility of a poorly water-soluble flavonoid. Naringin, a flavonoid glycoside, was studied as a model poorly water-soluble compound. Two surfactants (sodium lauryl sulfate and polyoxyethylene sorbitan monooleate (Tween 80)), and three cyclodextrins (CDs: β-CD, 2-hydroxypropyl-β-CD, and dimethyl-β-CD) were studied as co-solvents by measuring the solubilities of naringin at 298.15 K using high-performance liquid chromatography in water/co-solvent mixtures. The stability constants of the co-solvent/solute systems were evaluated by the Higuchi–Connors solubility method. According to these results, dimethyl-β-CD had the highest co-solvent effect among the CDs. Modeling of the experimental solubility data were performed using the modified Chrastil model.</p></div>","PeriodicalId":666,"journal":{"name":"Journal of Solution Chemistry","volume":"54 5","pages":"626 - 640"},"PeriodicalIF":1.4000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solution Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10953-025-01442-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of this work is to experimentally determine co-solvent effects on the solubility of a poorly water-soluble flavonoid. Naringin, a flavonoid glycoside, was studied as a model poorly water-soluble compound. Two surfactants (sodium lauryl sulfate and polyoxyethylene sorbitan monooleate (Tween 80)), and three cyclodextrins (CDs: β-CD, 2-hydroxypropyl-β-CD, and dimethyl-β-CD) were studied as co-solvents by measuring the solubilities of naringin at 298.15 K using high-performance liquid chromatography in water/co-solvent mixtures. The stability constants of the co-solvent/solute systems were evaluated by the Higuchi–Connors solubility method. According to these results, dimethyl-β-CD had the highest co-solvent effect among the CDs. Modeling of the experimental solubility data were performed using the modified Chrastil model.
期刊介绍：
Journal of Solution Chemistry offers a forum for research on the physical chemistry of liquid solutions in such fields as physical chemistry, chemical physics, molecular biology, statistical mechanics, biochemistry, and biophysics. The emphasis is on papers in which the solvent plays a dominant rather than incidental role. Featured topics include experimental investigations of the dielectric, spectroscopic, thermodynamic, transport, or relaxation properties of both electrolytes and nonelectrolytes in liquid solutions.
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