RNA modification: A contemporary review of pseudouridine (Ψ) and its role in functional plant biology

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Plant Science Pub Date : 2025-04-24 DOI:10.1016/j.plantsci.2025.112522

Ahsan Khan , Gatera Anicet , Hafiz Umair Asdullah , Muhammad Ahmad Hassan , Youhong Song

引用次数: 0

Abstract

Pseudouridine (Ψ) is a modified nucleoside present in diverse RNA species, including mRNA (messenger RNA), snRNA (small nuclear RNA), rRNA (ribosomal RNA) and tRNA (transfer RNA). In plants, Ψ serves a critical function in RNA modification, supporting the stability, structural integrity, and functionality of RNA molecules. This review provides the various roles that Ψ fulfils in the modification of plant RNA biology, encompassing effects on biosynthesis pathways, regulatory mechanisms, stability, and translation efficiency. Additionally, we discuss recent advancements in the dynamic regulation of Ψ deposition in response to environmental stimuli and stressors. Elucidating Ψ's roles contributes to the comprehension of plant biology and may facilitate developments in biotechnology and crop improvement.

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RNA修饰：伪尿嘧啶（Ψ）及其在功能性植物生物学中的作用的当代综述

伪尿苷（Ψ）是一种存在于多种RNA物种中的修饰核苷，包括mRNA（信使RNA）、snRNA（小核RNA）、rRNA（核糖体RNA）和tRNA（转移RNA）。在植物中，Ψ在RNA修饰中起着关键作用，支持RNA分子的稳定性、结构完整性和功能。本文综述了Ψ在植物RNA生物学修饰中的各种作用，包括对生物合成途径、调控机制、稳定性和翻译效率的影响。此外，我们讨论了在响应环境刺激和应激源的Ψ沉积动态调节方面的最新进展。阐明Ψ的作用有助于理解植物生物学，并可能促进生物技术和作物改良的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plant Science 生物-生化与分子生物学

CiteScore

9.10

自引率

1.90%

发文量

322

审稿时长

33 days

期刊介绍： Plant Science will publish in the minimum of time, research manuscripts as well as commissioned reviews and commentaries recommended by its referees in all areas of experimental plant biology with emphasis in the broad areas of genomics, proteomics, biochemistry (including enzymology), physiology, cell biology, development, genetics, functional plant breeding, systems biology and the interaction of plants with the environment. Manuscripts for full consideration should be written concisely and essentially as a final report. The main criterion for publication is that the manuscript must contain original and significant insights that lead to a better understanding of fundamental plant biology. Papers centering on plant cell culture should be of interest to a wide audience and methods employed result in a substantial improvement over existing established techniques and approaches. Methods papers are welcome only when the technique(s) described is novel or provides a major advancement of established protocols.